Browse our Research Articles

Page 620 of 1,459
    1. Evolutionary Biology
    2. Genetics and Genomics

    Cis-regulatory variants affect gene expression dynamics in yeast

    Ching-Hua Shih, Justin Fay
    Allele differences in gene expression dynamics are associated with insertions and deletions and are caused in part by multiple variants within the same promoter region.
    1. Genetics and Genomics

    CLAMP and Zelda function together to promote Drosophila zygotic genome activation

    Jingyue Duan, Leila Rieder ... Erica Larschan
    Maternal CLAMP functions as a novel pioneer transcription factor to open chromatin and plays a targeted yet essential role in Drosophila zygotic genome activation.
    1. Stem Cells and Regenerative Medicine

    Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

    Francis Grafton, Jaclyn Ho ... Mohammad Ali Mandegar
    Deep learning combined with induced pluripotent stem cell technology is an effective method to interrogate cellular phenotypes and predict patterns of cardiotoxicity in vitro.
    1. Developmental Biology
    2. Neuroscience

    Characterization of cephalic and non-cephalic sensory cell types provides insight into joint photo- and mechanoreceptor evolution

    Roger Revilla-i-Domingo, Vinoth Babu Veedin Rajan ... Kristin Tessmar-Raible
    Molecular, cellular and behavioral genetic approaches in Platynereis dumerilii indicate that r-Opsins can act as ancient, light-dependent modulators of mechanosensation, and suggest that light-independent mechanosensory roles of r-Opsins evolved secondarily.
    1. Cell Biology
    2. Developmental Biology

    Relish plays a dynamic role in the niche to modulate Drosophila blood progenitor homeostasis in development and infection

    Parvathy Ramesh, Nidhi Sharma Dey ... Lolitika Mandal
    Ecdysone-mediated regulation of Relish expression and activation in the hematopoietic niche is essential for progenitor maintenance in the Drosophila Lymph gland.
    1. Computational and Systems Biology
    2. Neuroscience

    Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction

    Nadiatou T Miningou Zobon, Joanna Jędrzejewska-Szmek, Kim T Blackwell
    ERK activation during induction of long-term synaptic plasticity is enhanced by synergistic interactions among signaling pathways mediated by the synaptically located GTPase-activating protein, and each pathway contributes to different ERK temporal dynamics.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Patterns of within-host genetic diversity in SARS-CoV-2

    Gerry Tonkin-Hill, Inigo Martincorena ... Wellcome Sanger Institute COVID-19 Surveillance Team
    Characterisation of within-host diversity of SARS-CoV-2 provides insights into the mutational and selective mechanisms driving its evolution and has important implications for using within-host variation to inform transmission inference efforts.
    1. Developmental Biology
    2. Neuroscience

    Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans

    Mizuki Kurashina, Jane Wang ... Kota Mizumoto
    Genetic analyses using a simple nervous system of the nematode revealed the novel function of the cell fate-determining transcriptional repressor complex in the differentiated neurons to determine the precise synapse position.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

    Miriam S Weber, Matthias Eibauer ... Ohad Medalia
    Keratins assemble into tubular filaments with a central density and exhibit structural heterogeneity, which is reflected in alterations of the helical arrangement.
    1. Stem Cells and Regenerative Medicine

    Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging

    Jacqueline A Larouche, Mahir Mohiuddin ... Carlos A Aguilar
    Muscle stem cells locally respond to perturbations of motor neurons and the neuromuscular junction.