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The human brain maintains a representation of latent task states within frontoparietal networks during the generalization of behaviors to novel settings.

The polymerase activity of PARP1 is converted to hydrolase activity upon binding of Histone Parylation Factor 1 (HPF1) with nucleosome activators.

Network topology and gene expression patterns in small cell lung cancer reveal two mutually opposing teams of regulators that enable multistability and consequent non-genetic heterogeneity, a clinically unsolved challenge.

Parathyroid hormone attenuates osteoarthritis pain and joint degeneration by modification of subchondral bone remodeling and could be a potential disease-modifying therapy for osteoarthritis.

Synaptotagmin-7 acts synergistically with synaptotagmin-1 by placing vesicles close to the plasma membrane within reach of the SNARE/Munc13-complex, supporting their priming and setting the stage for fast and slow fusion.

The fact that sexual activity/reproduction doubles the lifespan of certain rodent species is most likely linked to critical changes in the regulation of the hypothalamic–pituitary–adrenal stress axis.

Somatostatin interneurons are novel mediators of serotonergic modulation in entorhinal cortex via activation of 5-HT_2A receptors, a receptor involved in the etiology of different psychiatric disorders.

The dual functional protein, Gorab, associates with the Golgi as a dimer but as a monomer with the procentriole cartwheel protein, Sas6, to mediate centriole duplication.

Quantitative live-cell time-lapse imaging reveals that the spatial and temporal degree of cortical polarity domains reflects stem-cell division capacity in cells of the Arabidopsis plant leaf epidermis.

Dietary selenium supplementation confers to mice all of the short-term healthspan benefits of the longevity-promoting intervention methionine restriction, and thus may represent a method to promote healthy aging in mammals.