Browse our Research Articles

Page 619 of 1,446
    1. Microbiology and Infectious Disease

    KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

    Rajnish Kumar Singh, Yonggang Pei ... Erle S Robertson
    KSHV nullifies hypoxic restriction of DNA replication.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The fluoride permeation pathway and anion recognition in Fluc family fluoride channels

    Benjamin C McIlwain, Roja Gundepudi ... Randy B Stockbridge
    In the extremely selective fluoride channels from the bacterial Fluc family, fluoride ions access the pore via two points, an electropositive vestibule and a triad of conserved residues involved in anion recognition.
    1. Physics of Living Systems

    Propelling and perturbing appendages together facilitate strenuous ground self-righting

    Ratan Othayoth, Chen Li
    Animals can, and robots should, use different types of appendages together to propel and perturb themselves to self-right when overturned, a strenuous yet crucial locomotor task.
    1. Neuroscience

    Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis

    Sayali V Gore, Eric J James ... Carlos D Aizenman
    Chronic dysregulation of matrix-metalloproteinase 9, which is associated with some neurodevelopmental disorders, leads to local hyperconnectivity in the developing brain, resulting in altered sensory processing and increased seizure susceptibility.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

    James A Watson, Carolyne M Ndila ... Nicholas J White
    Complete blood count data can increase the accuracy of the diagnosis of severe malaria in children in high transmission settings.
    1. Developmental Biology
    2. Immunology and Inflammation

    Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

    Xia Liu, Jingjing Yu ... Xi Chen
    Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control checkpoint for thymocyte β-slection.
    1. Cell Biology
    2. Immunology and Inflammation

    RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination

    Ziwei Yang, Jun Wang ... Ersheng Kuang
    RTN3 is upregulated upon RNA viral infection, in turn suppresses antiviral responses by impairing TRIM25-mediated RIG-I K63-linked polyubiquitination and decreases neutrophil populations and inflammatory infiltration, representing a novel inflammatory resolution.
    1. Microbiology and Infectious Disease

    Revisiting the guidelines for ending isolation for COVID-19 patients

    Yong Dam Jeong, Keisuke Ejima ... Marco Ajelli
    Compared with the approach isolating COVID-19 patients for a fixed period, the approach using repeated PCR testing mitigates unnecessarily lengthy isolation of patients while minimizing the risk of further transmission.
    1. Genetics and Genomics

    miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging

    Isabelle Schiffer, Birgit Gerisch ... Adam Antebi
    Coordinate control of lysosomal v-ATPase subunits and biogenesis factor TFEB by miR-1 identifies a key regulatory axis with strong links to age-related proteotoxic disease.
    1. Microbiology and Infectious Disease

    A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Dayana C Farhat, Matthew W Bowler ... Christopher Swale
    The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.