Browse our Research Articles

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    1. Immunology and Inflammation
    2. Medicine

    Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

    Dongjin Jeong, Hye Sung Kim ... Doo Hyun Chung
    Soluble Fas ligand interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as death receptor 5, exacerbating arthritis in a Fas-independent manner.
    1. Cell Biology

    ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells

    Maria F Ullo, Jeremy S Logue
    Fast amoeboid migrating cells require both cofilin-1 and ADF for fast actin turnover at 'leader bleb' necks.
    1. Microbiology and Infectious Disease

    Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloem

    Qian Chen, Yuyan Liu ... Taiyun Wei
    An important rice reovirus hijacks exosomes to traverse the apical plasmalemma into saliva-stored cavities in the salivary glands of insect vectors, facilitating viral horizontal transmission into rice phloem.
    1. Evolutionary Biology
    2. Neuroscience

    Connectional asymmetry of the inferior parietal lobule shapes hemispheric specialization in humans, chimpanzees, and rhesus macaques

    Luqi Cheng, Yuanchao Zhang ... Tianzi Jiang
    Humans showed the most widespread asymmetric connectivity between the inferior parietal lobule subregions and the rest of the brain compared to macaques and chimpanzees, which shapes hemispheric specialization in primates.
    1. Chromosomes and Gene Expression

    The molecular basis of coupling between poly(A)-tail length and translational efficiency

    Kehui Xiang, David P Bartel
    For poly(A)-tail length to influence mRNA translational efficiency, poly(A)-binding protein (PABPC) must be limiting, mRNAs lacking PABPC must be stable, and translation initiation must be sensitive to PABPC levels.
    1. Immunology and Inflammation

    Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

    Daisy X Ji, Kristen C Witt ... Russell E Vance
    Repression of type I interferons by SP140 is essential for resistance to Legionella pneumophila and Mycobacterium tuberculosis.
    1. Cell Biology
    2. Computational and Systems Biology

    CDK control pathways integrate cell size and ploidy information to control cell division

    James Oliver Patterson, Souradeep Basu ... Paul Nurse
    DNA concentration, cyclin levels, phosphatase activity, and CDK phosphorylation combine to directly link cell size to cell division.
    1. Cell Biology

    A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval

    Andreas Gerondopoulos, Philipp Bräuer ... Simon Newstead
    KDEL receptor structures with variant HDEL and RDEL signals help decode the cell biological mechanism for the selective retrieval of escaped endoplasmic reticulum luminal proteins.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

    Anthony S Findley, Alan Monziani ... Francesca Luca
    Investigation of dynamic gene regulation across cell types and environments reveals new GxE regulatory loci that are important for disease.
    1. Neuroscience

    Interneuron-specific gamma synchronization indexes cue uncertainty and prediction errors in lateral prefrontal and anterior cingulate cortex

    Kianoush Banaie Boroujeni, Paul Tiesinga, Thilo Womelsdorf
    A fast spiking interneuron sub-type in medial and lateral prefrontal cortex fires and gamma-synchronizes prominently during adaptive learning of reward values when outcomes are uncertain and choice options have similar values.