Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
Artificial selection for increased tibia length in mice made their skulls longer, narrower, and flatter, suggesting that even distant skeletal regions can evolve as correlated responses to selection acting locally.
Stéphanie Torrino, Victor Tiroille ... Stephan Clavel
UBTD1 coordinates EGFR signaling by modulating ceramides level through ASAH1 ubiquitination and EGFR degradation through SQSTM1/p62 ubiquitination, which together impact cell proliferation.
Radhia Kacher, François-Xavier Lejeune ... Alexandra Durr
Somatic instability of the CAG repeat increases progressively with age and disease progression in Huntington disease mutation carriers, starting with low levels in fetal brain tissues.
Actively regulated immune memory differentiation, with a preference for cross-reactive receptors with moderate affinity against pathogens as opposed to high-affinity receptors, confers a long-term benefit to the host.
Minimal essential features of Rho GTPase systems are elucidated that regulate the number of distinct domains developed by a cell’s polarity machinery, which in turn governs cell shape.
Rahul Chadda, Nathan Bernhardt ... Janice L Robertson
Differences in the lipid solvation energetics of associated and dissociated states is a primary driving force for membrane protein oligomerization, presenting a molecular mechanism for lipid regulation in biology.
Axon guidance molecules DCC and NTN1 regulate astroglial-mediated interhemispheric remodelling required for corpus callosum formation in humans and mice.
Matthew T Parker, Katarzyna Knop ... Gordon G Simpson
The expression of Arabidopsis NLR immune response genes is modulated by premature transcription termination, and this has implications for understanding NLR regulation and evolutionary dynamics.
