Browse our Research Articles

Seasonal selection is a general feature of Drosophila melanogaster genetic variation, occurring in North American and European populations and affecting large proportions of the genome.

The association of caveolin with the potassium channel Kv1.3 fine-tunes cell survival and apoptosis.

A new mode of inflammasome regulation was discovered through a mouse strain intercross that identified the Pycard locus was associated with IL-1β release, and gene editing showed this was due to an SNP in the Pycard mRNA regulating its turnover.

A new disposition mechanism for glucuronides, where liver serves as recycle organ and intestine serves as metabolism organ, is established to better explain the disposition of phenolics in vivo.

Loss of heterozygosity (LOH) mediated diversification of the diploid S. cerevisiae hybrid genomes during asexual propagation are vast and exceptionally varied depending on the genetic background.

Although primary sensory neuron-derived calcitonin gene-related peptide (CGRP) contributes to the processing of pain messages, an understudied population of dorsal horn CGRP-expressing interneurons also contributes to the processing of mechanical sensitivity.

Ketogenic diet protects against coronavirus-infected aged mice, which, like humans, are significantly more susceptible to infections, by deactivating NLRP3 inflammasome, reducing pathogenic monotypes, and expanding γδ T cells in the lung.

The E3 ubiquitin ligase complex linear ubiquitin chain assembly complex (LUBAC) forms a branched chain on linear ubiquitin chains depending on the RING-in-between-RING-type E3 ligase heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1L).

Neuroanatomical studies reveal presence and cholinergic phenotype of 150,000-200,000 extrahypothalamic gonadotropin-releasing hormone neurons in human basal ganglia and basal forebrain, and RNA-sequencing detects gonadotropin-releasing hormone receptor-1 expression in cholinergic interneurons but not in spiny projection neurons of the human putamen.

During intestinal development, apical PAR complex proteins keep apical domains and junctions continuous between cells as they divide and elongate, and ultimately build a continuous functional tube.