Browse our Research Articles

Page 633 of 1,392
    1. Microbiology and Infectious Disease

    Redox controls RecA protein activity via reversible oxidation of its methionine residues

    Camille Henry, Laurent Loiseau ... Benjamin Ezraty
    RecA is inactivated by oxidative stress and repaired by the MsrA/B anti-ROS defense system.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary dynamics of transposable elements in bdelloid rotifers

    Reuben W Nowell, Christopher G Wilson ... Timothy G Barraclough
    An investigation of transposable element evolution in a group of long-term asexual animals shows that many of the predicted effects of asexuality are not observed.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

    Alicia Tapias, David Lázaro ... Zhao-Qi Wang
    The Trrap-HAT-Sp1 axis operates a conserved transcriptional program to control proper microtubule dynamics in brain homeostasis and prevents neurodegeneration.
    1. Cell Biology

    LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

    Nana Naetar, Konstantina Georgiou ... Roland Foisner
    The lamin A/C binding protein LAP2α inhibits formation of higher order lamin structures in the nuclear interior in a lamin A/C-phosphorylation-independent manner, thereby regulating chromatin mobility.
    1. Microbiology and Infectious Disease

    Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo

    Darryl A Wesener, Zachary W Beller ... Jeffrey I Gordon
    A method has been developed to characterize the expressed biochemical activities of gut microbial communities using retrievable, microscopic, fluorescent-labeled glass beads containing chemically bound surface biomolecules.
    1. Cell Biology
    2. Developmental Biology

    A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

    Neta Erez, Lena Israitel ... Amir Orian
    A nuclear Non-stop identity complex (NIC) supervises enterocyte (EC) identity, preserves tissue homeostasis, and prevents premature aging by maintaining EC-specific gene expression, silencing non-relevant programs, and safeguarding large-scale nuclear organization.
    1. Neuroscience

    Brain endothelial cell TRPA1 channels initiate neurovascular coupling

    Pratish Thakore, Michael G Alvarado ... Scott Earley
    Activation of TRPA1 channels on cerebral capillary endothelial cells initiates a retrograde signal that propagates and dilates upstream arterioles.
    1. Neuroscience

    Incomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse

    Timothy S Balmer, Carolina Borges-Merjane, Laurence O Trussell
    Extracellular levels of the neurotransmitter glutamate are maintained at physiologically significant levels at some synapses even in the absence of action potentials.
    1. Developmental Biology

    Deficient spermiogenesis in mice lacking Rlim

    Feng Wang, Maria Gracia Gervasi ... Ingolf Bach
    Genetic analyses in mice identifies Rlim in the spermatogenic cell lineage as a regulator of cytoplasmic reduction during spermiogenesis.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Repeated outbreaks drive the evolution of bacteriophage communication

    Hilje M Doekes, Glenn A Mulder, Rutger Hermsen
    Mathematical modelling suggests that the evolution of communication between bacterial viruses requires repeated outbreak events, and the model then predicts typical communication strategies.