Browse our Research Articles

Page 666 of 1,378
    1. Cell Biology

    BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

    Chang Zhang, Chanjuan Hao ... Wei Li
    BLOS1 is a new regulator of LDLR endosomal recycling through coordinating kinesins during long-range transport, and depletion of BLOS1 in mouse liver leads to aberrant lipid metabolism.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

    James B Eaglesham, Kacie L McCarty, Philip J Kranzusch
    Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

    Allen Wang, Joshua Chiou ... NHLBI LungMap Consortium
    Generation of a human lung single nucleus ATAC-seq and single nucleus RNA-seq datasets reveals candidate cis-regulatory elements that advance knowledge on gene expression control in normal and diseased lungs.
    1. Neuroscience

    Fine-scale computations for adaptive processing in the human brain

    Elisa Zamboni, Valentin G Kemper ... Zoe Kourtzi
    Laminar fMRI reveals that adaptive processing involves recurrent processing within visual cortex and top-down influences from posterior parietal cortex via feedback.
    1. Cell Biology
    2. Developmental Biology

    Zebrafish Posterior Lateral Line primordium migration requires interactions between a superficial sheath of motile cells and the skin

    Damian E Dalle Nogare, Naveen Natesh ... Ajay B Chitnis
    Epithelial cells utilize a covering sheath of motile cells to migrate in confinement.
    1. Ecology
    2. Physics of Living Systems

    Efficient mate finding in planktonic copepods swimming in turbulence

    François-Gaël Michalec, Itzhak Fouxon ... Markus Holzner
    Calanoid copepods achieve efficient mate finding in turbulence through active swimming and turbulence advection, indicating that reproduction is not restricted to spatial and temporal windows of calm hydrodynamic conditions.
    1. Stem Cells and Regenerative Medicine

    Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells

    Balyn W Zaro, Joseph J Noh ... Irving L Weissman
    Mass spectrometry exposes a post-transcriptionally regulated reduction in protein diversity in hematopoietic stem cells, including a lack of detectable Dnmt3a protein levels despite mRNA levels comparable to progenitors.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

    Qi Yang, Thomas A Hughes ... Sriram Neelamegham
    A critical role for glycosylation on viral entry and methods to use this knowledge to reduce SARS-CoV-2 infectivity has been demonstrated.
    1. Genetics and Genomics

    Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross

    Kaushik Renganaath, Rockie Chong ... Frank W Albert
    Yeast promoters can harbor multiple natural DNA variants that influence gene expression, interact genetically, evolve under negative selection, alter transcription factor motifs, and remain challenging to predict.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Recurrent evolution of high virulence in isolated populations of a DNA virus

    Tom Hill, Robert L Unckless
    The same host–virus interactions can evolve multiple times in nature, due to the high effective mutation rate of viruses, and provide interesting systems of study.