Browse our Research Articles

Page 667 of 1,404
    1. Cell Biology
    2. Developmental Biology

    The ESCRT machinery regulates retromer-dependent transcytosis of septate junction components in Drosophila

    Hendrik Pannen, Tim Rapp, Thomas Klein
    A novel role of endosomal machineries retromer and ESCRT in membrane delivery of Drosophila septate junction components is required for maintenance of junction integrity and epithelial barrier function.
    1. Neuroscience

    Microsecond interaural time difference discrimination restored by cochlear implants after neonatal deafness

    Nicole Rosskothen-Kuhl, Alexa N Buck ... Jan WH Schnupp
    Early deaf human CI users are often insensitive to sub-millisecond interaural time differences (ITDs); however, with synchronized CIs, early deafened rats learned to lateralize small ITDs near 50 µs.
    1. Developmental Biology

    The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

    Aynur Kaya-Çopur, Fabio Marchiano ... Frank Schnorrer
    Muscle fiber growth during development is controlled by the Hippo pathway that links the assembly state of the contractile sarcomeres with the transcriptional state of the sarcomeric genes.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci

    Reza K Hammond, Matthew C Pahl ... Struan FA Grant
    By integrating GWAS data sets with ATAC-seq and promoter-focused Capture C data, one can uncover further loci beyond those that reach genome-wide significance (p<5x10-8).
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Proofreading through spatial gradients

    Vahe Galstyan, Kabir Husain ... Rob Phillips
    Theoretical study shows how enzymes can achieve substrate proofreading by taking advantage of existing molecular gradients in the cell while not being endowed with structural features typically required for proofreading.
    1. Cancer Biology

    Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

    Krystal Ann Orlando, Amber K Douglas ... Bernard E Weissman
    BRG1 loss drives initiation and progression in human cancers through changes in specific differentiation programs in an AP-1-dependent manner.
    1. Microbiology and Infectious Disease

    Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping

    Philip P Adams, Gabriele Baniulyte ... Joseph T Wade
    Multiple RNA-seq approaches globally mapped RNA 3´ ends resulting in the discovery of numerous and diverse RNA regulators.
    1. Neuroscience

    Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network

    Jeong-Kyu Han, Sun-Ho Kwon ... Sang Jeong Kim
    Cerebellar STAT3 is indispensable for proper expression of fear memory network processing.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus

    David W Hawman, Kimberly Meade-White ... Heinz Feldmann
    A mouse-adapted strain of Crimean-Congo hemorrhagic fever virus that recapitulates human disease in wild-type mice significantly improves our ability to study Crimean-Congo hemorrhagic fever virus pathogenesis.
    1. Neuroscience

    Amplitude modulations of cortical sensory responses in pulsatile evidence accumulation

    Sue Ann Koay, Stephan Thiberge ... David W Tank
    From as early as primary visual cortex and across posterior cortical areas, neural responses to visual pulses during an evidence-accumulation task exhibit a multitude of task-related amplitude modulations/gain changes.