Browse our Research Articles

Page 671 of 1,380
    1. Neuroscience

    Defective memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome

    Jie Li, Rena Y Jiang ... Lu Chen
    Activity-dependent genetic labeling during behavioral learning shows Fragile-X syndrome model mice exhibit impaired hippocampal engram reactivation, and that enriched environment experience improves fear memory retrieval by enhancing engram reactivation efficacy.
    1. Neuroscience

    The amygdala instructs insular feedback for affective learning

    Dominic Kargl, Joanna Kaczanowska ... Wulf Haubensak
    Hierarchical information flow in a cortico-limbic loop between the insular cortex, central amygdala and the cholinergic basal forebrain links bodily states with environmental stimuli to guide fear and reward behavior.
    1. Neuroscience

    A new no-report paradigm reveals that face cells encode both consciously perceived and suppressed stimuli

    Janis Karan Hesse, Doris Y Tsao
    Conscious visual percepts are encoded by face patches in the absence of report, can be decoded from population recordings, and are multiplexed with the veridical physical stimulus.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster

    Yicheng Luo, Elena Fefelova ... Alexei A Aravin
    SUMO-dependent pathway is responsible for selective repression of damaged rDNA and silencing of intact surplus units revealing an epigenetic mechanism that controls the differential expression of identical sequences in the same cell.
    1. Immunology and Inflammation

    MicroRNAs of the miR-17~92 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression

    Xiang Zhang, Jianguo Liu ... Xiaoyu Hu
    miR-17~92 family of miRNAs control the balance between pro- and anti-inflammatory cytokines in adipose tissue macrophages, the absence of which leads to disturbed adipose homeostasis.
    1. Plant Biology

    The genetic architecture of host response reveals the importance of arbuscular mycorrhizae to maize cultivation

    M Rosario Ramírez-Flores, Sergio Perez-Limon ... Ruairidh JH Sawers
    Heritable variation in the benefit maize plants receive from arbuscular mycorrhizal fungi supports the feasibility of breeding crops to optimize use of this ancient symbiosis.
    1. Computational and Systems Biology
    2. Neuroscience

    Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics

    Jonathan Oesterle, Christian Behrens ... Philipp Berens
    Bayesian simulator-based inference is used to infer the parameters of complex multicompartment models of retinal neurons from two-photon imaging data.
    1. Cell Biology
    2. Immunology and Inflammation

    Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells

    Elizabeth Rivers, Rajeev Rai ... Adrian J Thrasher
    WASp is an immunometabolic regulator of human myeloid cells and regulates autophagy and mitochondrial homeostasis.
    1. Chromosomes and Gene Expression

    Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model

    Jade Hebras, Virginie Marty ... Jérôme Cavaille
    Knockout of Snord115 has mild impact on expression and function of the serotonin 2C receptor.
    1. Neuroscience

    Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly

    Tyler G Ekins, Vivek Mahadevan ... Chris J McBain
    An excess of novel non-canonical subtypes of parvalbumin+ interneurons in a mouse model of classical lissencephaly, which possess non-fast-spiking physiological properties, may contribute to network hyperexcitability common in this model.