Damien Lemoine, Sarah Mondoloni ... Alexandre Mourot
A photoswitchable pore blocker was covalently attached to a cysteine-substituted glutamate delta 2 receptor, to provide optical control of its ion channel function.
Priscilla S-W Yeung, Christopher E Ing ... Murali Prakriya
Electrophysiological and molecular modeling studies identify a sulfur-aromatic interaction between the hydrophobic channel gate and a nearby methionine residue, termed the "gate latch", which is essential for Orai1 pore opening.
Slug chloroplasts avoid damage to photosynthesis by maintaining an oxidized electron transfer chain with the help of oxygen-sensitive electron acceptors.
A quantitative live imaging approach unveils that earliest neurogenic progenitors in the vertebrate retina arise from asymmetric divisions and that this asymmetry involves Notch signalling through the endocytic pathway.
Social dominance has opposing effects on behavior following stress in male vs. female mice indicating an important role in sex differences in the stress response.
Jamie C Little, Elisa Garcia-Garcia ... Daniel Kalderon
Hedgehog acts as a morphogen by regulating proteolytic processing and activation of full-length Ci/Gli transcriptional effectors but can pattern Drosophila wing discs normally in the absence of regulated proteolytic processing.
Shubhanshi Trivedi, Daniel Labuz ... Daniel T Leung
Mucosal-associated invariant T (MAIT) cells, highly activated and dysfunctional in sepsis patients, contribute to tissue-specific cytokine responses that are protective against mortality during experimental sepsis.
Single molecule FISH analysis defines the behavior of centromere-derived alpha-satellite transcripts in intact human cells and reveals a critical role for centromere-nucleolar contacts in repressing alpha-satellite transcription.
