Huiliang Zhang, Nathan N Alder ... Peter S Rabinovitch
The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
Teeth and dermal odontodes diverge from the same set of founder odontodes, demonstrating they are modified subsets of the same system, and both oral and dermal epithelial have patterning capacity.
In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
Applying bioorthogonal chemistry to the zebrafish/Mycobacterium marinum model of tuberculosis reveals that the virulence lipid PDIM must spread into epithelial cells in order for mycobacteria to establish infection.