Browse our Research Articles

Page 687 of 1,423
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

    Salah A Baker, Wesley A Leigh ... Kenton M Sanders
    An optogenetic dual-color Ca2+-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Cajal, modulate smooth-muscle responses and drive colonic motility via complex Ca2+ signaling.
    1. Ecology

    A gustatory receptor tuned to the steroid plant hormone brassinolide in Plutella xylostella (Lepidoptera: Plutellidae)

    Ke Yang, Xin-Lin Gong ... Chen-Zhu Wang
    The gustatory receptor PxylGr34 is tuned to the steroid plant hormone brassinolide and mediates the deterrent effects of brassinolide on feeding and ovipositing behaviors in Plutella xylostella.
    1. Genetics and Genomics
    2. Neuroscience

    Fruitless mutant male mosquitoes gain attraction to human odor

    Nipun S Basrur, Maria Elena De Obaldia ... Leslie B Vosshall
    Engineering male mosquitoes lacking the fruitless gene induces them to be attracted to humans.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structure of dual BON-domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation

    Jack Alfred Bryant, Faye C Morris ... Ian R Henderson
    Analysis of the E. coli protein DolP reveals the first dual BON-domain structure and identifies phospholipid binding as a new mechanism for protein localisation to the outer membrane division site.
    1. Developmental Biology

    Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models

    Kyeong-Hye Moon, Ji-Hyun Ma ... Jinwoong Bok
    Developmental defects of the cochlea caused by dysregulation of sonic hedgehog signaling are the potential etiology for hearing loss in a group of ciliopathies with defective ciliogenesis.
    1. Neuroscience

    Using the past to estimate sensory uncertainty

    Ulrik Beierholm, Tim Rohe ... Uta Noppeney
    For perceptual inference, human observers do not estimate sensory uncertainty instantaneously from the current sensory signals alone, but by combining past and current sensory inputs consistent with a Bayesian learner.
    1. Chromosomes and Gene Expression

    Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

    Mark C Johnson, Geylani Can ... Philip Zegerman
    The S-phase checkpoint has roles in all phases of the cell cycle, which has implications for the majority of cancers that lack cell cycle controls.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Mixed cytomegalovirus genotypes in HIV-positive mothers show compartmentalization and distinct patterns of transmission to infants

    Juanita Pang, Jennifer A Slyker ... Judith Breuer
    Genomic analyses provide new insights into natural history and pathogenesis of cytomegalovirus infection and suggest new testable hypotheses that could be important for the design and implementation of new vaccines.
    1. Neuroscience

    Oxytocin modulates human chemosensory decoding of sex in a dose-dependent manner

    Kepu Chen, Yuting Ye ... Wen Zhou
    Oxytocin, but not the structurally similar vasopressin, modulates both the chemosensory decoding of femininity in straight men and that of masculinity in gay men in an inverted-U-shaped manner.
    1. Immunology and Inflammation

    Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses

    Risa Ebina-Shibuya, Erin E West ... Warren J Leonard
    Immunological analysis of wild-type and Crlf2-/- mice reveals a role for the cytokine thymic stromal lymphopoietin on memory CD8+ T-cell responses to viral infection, findings with potential translational implications.