Browse our Research Articles

Page 692 of 1,380
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Serine phosphorylation regulates the P-type potassium pump KdpFABC

    Marie E Sweet, Xihui Zhang ... David L Stokes
    Phosphorylation of a highly conserved serine residue is a physiological response of Escerichia coli to environmental potassium levels that inhibits transport by KdpFABC to maintain cellular homeostasis.
    1. Cell Biology
    2. Developmental Biology

    Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis

    Cuie Chen, Yukiko M Yamashita
    Alms1a is a centrosomal protein that exhibits asymmetric localization between mother and daughter centrosomes in asymmetrically dividing stem cells in Drosophila testis, controlling centriole duplication.
    1. Cell Biology
    2. Developmental Biology

    Keratins and plakin family cytolinker proteins control the length of epithelial microridge protrusions

    Yasuko Inaba, Vasudha Chauhan ... Alvaro Sagasti
    Although intermediate filaments are not widely known to contribute to the morphogenesis of cellular protusions, keratin filaments and cytolinkers are critical for the development of microridge protrusions in zebrafish skin.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genetic factors of bilaterian evolution

    Peter Heger, Wen Zheng ... Thomas Wiehe
    Advanced orthology clustering of bilaterian and non-bilaterian sequences identifies 157 bilaterian-specific genes which are linked to key morphological features of this animal group.
    1. Neuroscience

    Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD

    Da Hee Jung, Sung Min Ahn ... Byung Tae Choi
    High-definition anodal transcranial stimulation alleviated cognitive deficits, affected dopaminergic neurotransmission factors, increased expression of several neurotrophic factors involving brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis.
    1. Developmental Biology

    Extensive and diverse patterns of cell death sculpt neural networks in insects

    Sinziana Pop, Chin-Lin Chen ... Darren W Williams
    Developmental cell death plays a key role during insect neurogenesis and is increased in specific neuronal populations in flies that have evolved flightlessness.
    1. Developmental Biology

    m6A RNA methylation impacts fate choices during skin morphogenesis

    Linghe Xi, Thomas Carroll ... Elaine Fuchs
    METTL3-mediated m6A modification maintains proper cell lineage specification during skin epithelium morphogenesis by coupling transcription and translation of key regulatory pathways.
    1. Cancer Biology

    A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

    Haojie Jin, Siying Wang ... Rene Bernards
    Combination of glutaminase inhibitor CB-839 and ASCT2 inhibitor V-9302 showed efficient antitumor effect against glutamine addicted liver cancer cells via glutathione depletion and reactive oxygen species (ROS) induction.
    1. Neuroscience

    M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s disease

    Sara Fernández-García, Sara Conde-Berriozabal ... Mercè Masana
    M2 cortex-dorsolateral striatum circuit is functionally altered in Huntington's disease and, by boosting its activity, we reverse symptoms at behavioral, physiological, and morphological level in symptomatic mice.
    1. Neuroscience

    Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system

    Hiromasa Takemura, Nicola Palomero-Gallagher ... Karl Zilles
    Polarized light imaging demonstrates detailed organization of projection, callosal, longitudinal association and short association fibers in the primate visual system at micrometer-resolution.