Yusuke Sugasawa, Wayland WL Cheng ... Alex S Evers
Differential, state-dependent occupancy of three discrete binding sites on α1β3 GABAA receptors determines whether a specific neurosteroid analogue potentiates or inhibits GABA-elicited currents or competitively antagonizes neurosteroid action.
The elongation rate of RNA polymerase II broadly affects the profile of poly(A) sites, and hence 3' mRNA isoforms, and it can mediate alternative polyadenylation in response to environmental conditions.
Trayambak Pathak, Maxime Gueguinou ... Mohamed Trebak
Colorectal tumors down-regulate the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX) to alter mitochondrial Ca2+ signaling and initiate transcriptional and metabolic reprogramming that drives tumor chemo-resistance and metastasis.
Sumeda Nandadasa, Jason M Szafron ... Suneel S Apte
Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
Adam C Lu, Christine Kyuyoung Lee ... Mark P Beenhakker
A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.
Clemens Christoph Döring, Suman Kumar ... Harald Hausen
The employment of xenopsin in ciliary and mixed microvillar/ciliary eye sensory cells in several protostome animals suggests high evolutionary plasticity of photoreceptors.
A stepped-wedge randomised controlled trial shows that early antiretroviral therapy (ART) initiation does not negatively affect the economic welfare of HIV patients in a low-income country.
Laura Crowley, Francesco Cambuli ... Michael M Shen
Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.
Unbiased analyses highlight context-specific crosstalk between Notch, DNA damage response genes, and PP2A, and provide a roadmap for understanding how Notch induces squamous cell differentiation.
