Browse our Research Articles

Page 739 of 1,392
    1. Computational and Systems Biology

    A decentralised neural model explaining optimal integration of navigational strategies in insects

    Xuelong Sun, Shigang Yue, Michael Mangan
    The first biology-constrained neural model of insect navigation guidance systems was explained including path integration, visual homing and route following, and their optimal coordination.
    1. Developmental Biology
    2. Neuroscience

    Extrinsic activin signaling cooperates with an intrinsic temporal program to increase mushroom body neuronal diversity

    Anthony M Rossi, Claude Desplan
    The activin ligand myoglianin acts as a temporal extrinsic cue to regulate the intrinsic temporal factor Imp in mushroom body neuroblasts, increasing neuronal diversity by specifying the α’β’ fate.
    1. Neuroscience

    Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus

    Meiqi Niu, Daniele Impieri ... Karl Zilles
    The macaque monkey intraparietal sulcus encompasses 17 cyto- and receptorarchitectonically distinct areas, which can be grouped into three clusters based on (dis)similarities of their molecular structure.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction

    Jan Hendrik van Weerd, Rajiv A Mohan ... Vincent M Christoffels
    Multiple variant transcriptional regulatory elements in >1 megabasepairs of noncoding DNA close to TBX3 affect gene expression and atrioventricular conduction system function in vivo.
    1. Neuroscience

    Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples

    Hong-Viet Ngo, Juergen Fell, Bernhard Staresina
    Triggered by (long-duration) hippocampal ripples, spindles facilitate communication between the hipppocampus and neocortex during natural sleep.
    1. Neuroscience

    Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times

    Lili X Cai, Katherine Pizano ... Ilana B Witten
    Dopamine neurons in medial versus lateral VTA encode different signals during fear extinction, yet inhibition of both populations influences fear extinction, at different times.
    1. Cell Biology
    2. Developmental Biology

    LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

    Laura Bozal-Basterra, María Gonzalez-Santamarta ... Rosa Barrio
    LUZP1 is required for proper cilia and cytoskeleton formation.
    1. Developmental Biology
    2. Evolutionary Biology

    Transient role of the middle ear as a lower jaw support across mammals

    Neal Anthwal, Jane C Fenelon ... Abigail S Tucker
    The incus of the middle ear plays a role in supporting the lower jaw prior to the formation of the mammalian jaw joint allowing early feeding in monotremes and marsupials.
    1. Cancer Biology

    Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

    CheukMan C Au, John B Furness ... Kristy A Brown
    3D culture of breast cancer in biologically relevant ECM potentiates the growth-inhibitory effects of unacylated ghrelin and AZP-531, and clinical response may be predictable based on a MAPK gene signature.
    1. Cell Biology
    2. Physics of Living Systems

    Golgi compartments enable controlled biomolecular assembly using promiscuous enzymes

    Anjali Jaiman, Mukund Thattai
    By partitioning promiscuous enzymes across multiple Golgi compartments, eukaryotic cells can tightly control the synthesis of complex sugar oligomers.