Browse our Research Articles

Page 848 of 1,383
    1. Developmental Biology

    TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish

    Jonathan Fillatre, Jean-Daniel Fauny ... Bernard Thisse
    Transcription factors downstream of Hippo signaling control formation of the Left-Right Organizer by regulating major signaling pathways, expression of transcription factors and regulators of epigenetic programming involved in this process.
    1. Epidemiology and Global Health
    2. Medicine

    Seasonal variation and etiologic inferences of childhood pneumonia and diarrhea mortality in India

    Daniel S Farrar, Shally Awasthi ... Prabhat Jha
    Nationally-representative verbal autopsies can be linked to seasonal patterns, clinical syndromes, and climate regions to describe novel insights regarding the microbiologic etiologies of childhood pneumonia and diarrhea in India.
    1. Structural Biology and Molecular Biophysics

    Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

    Yihe Huang, Becca Roth ... Juan Du
    High-resolution structures of human TRPM2 in different functional states provided the mechanism underlying ligand recognition, channel activation and inhibition.
    1. Ecology
    2. Evolutionary Biology

    Intergenerational effects of early adversity on survival in wild baboons

    Matthew N Zipple, Elizabeth A Archie ... Susan C Alberts
    In wild baboons, a female's adverse early experiences can influence her offspring's survival years after the original adversity was experienced.
    1. Ecology
    2. Evolutionary Biology

    Tooth fracture frequency in gray wolves reflects prey availability

    Blaire Van Valkenburgh, Rolf O Peterson ... John A Vucetich
    Despite risks of infection and reduced fitness, tooth fracture frequency in gray wolves increases rapidly when prey are scarce because they must consume carcasses more completely.
    1. Computational and Systems Biology
    2. Neuroscience

    Population adaptation in efficient balanced networks

    Gabrielle J Gutierrez, Sophie Denève
    Neural populations may depend on balanced recurrent connectivity to produce an efficient stimulus representation while also maintaining an accurate stimulus encoding despite the variability introduced by adapting neural responses.
    1. Genetics and Genomics

    Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation

    Thomas A Sasani, Brent S Pedersen ... Aaron R Quinlan
    Rates of germline mutation accumulation are highly variable across families of similar genetic ancestry, and post-zygotic mosaicism is a substantial source of de novo mutations.
    1. Microbiology and Infectious Disease

    Visualizing trypanosomes in a vertebrate host reveals novel swimming behaviours, adaptations and attachment mechanisms

    Éva Dóró, Sem H Jacobs ... Maria Forlenza
    The transparent zebrafish reveals the reality of trypanosomes swimming in a vertebrate host, and their adaptations to an extremely heterogenic environment.
    1. Microbiology and Infectious Disease

    The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

    Ashley M Ngo, Matthew J Shurtleff ... Andreas S Puschnik
    The ER membrane protein complex (EMC) facilitates the correct topology of the flavivirus non-structural proteins NS4A and NS4B at the ER membrane critical for viral replication.
    1. Cell Biology
    2. Physics of Living Systems

    Myosin II isoforms play distinct roles in adherens junction biogenesis

    Mélina L Heuzé, Gautham Hari Narayana Sankara Narayana ... Benoit Ladoux
    Myosin isoforms exhibit different functions in the formation of adherens junctions and the transmission of mechanical forces.