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Tau deposition in the aging brain follows patterns of functional connectivity that correspond to specific neural memory networks, and this relationship is strengthened in the presence of amyloid-β.

Perivascular extracellular vesicles induce bone repair, and do so via tetraspanin binding to recipient skeletal progenitor cells.

DNA replication initiation proteins contain a disordered domain that impacts each stage of their function, from chromatin recruitment and initiator co-assembly to the subsequent displacement of the factors from chromatin.

iRICC, a new method to identify RNA-RNA interactions in vivo, provides mechanistic insight into the function of a viral non-coding RNA.

Gating currents analysis at different Ca²⁺ concentrations of BK channels reveals a strong allosteric coupling between Ca²⁺- and voltage-sensing modules via equivalent contributions exerted by the RCK1 and RCK2 Ca²⁺-sites.

ATP enters the endoplasmic reticulum (ER) lumen through an SLC35B1/AXER-dependentCaATiER mechanism, and ATP usage in the ER renders 'anti-Warburg' effect by increasing ATP regeneration from OxPhos while decreasing glycolysis.

A combination of mouse genetics and biochemistry approaches reveals neurexophilin4 (Nxph4) as a context-specific α-neurexin ligand, which regulates Golgi-granule cell inhibitory synapses and motor functions.

Mitochondrial dysfunction in neural stem cells and brain tumour cells decreases proliferation and affects the generation of neuronal diversity and tumour heterogeneity.

Cryo-EM studies reveal structural basis for the activation, auto-inhibition and regulation of RET receptor tyrosine kinase.

A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.