Egor Svidritskiy, Gabriel Demo ... Andrei A Korostelev
Ensemble cryo-EM visualizes how structural rearrangements poise the newly made protein and release factor RF2 to dissociate in preparation for ribosome recycling.
A key cellular stress granule protein, G3BP1, is critical for efficient norovirus infection, representing the first pan-norovirus, pro-viral factor identified to date.
Oleksandr Yagensky, Mahdokht Kohansal-Nodehi ... John JE Chua
Increased levels of brain Hebp1 starting from the presymptomatic stage of Alzheimer’s disease contributes to progressive neuronal loss by triggering mitochondrial-dependent apoptosis in neurons exposed to elevated heme.
Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.
Michael R McLaren, Amy D Willis, Benjamin J Callahan
A mathematical model of bias in marker-gene and metagenomic sequencing measurements explains systematic errors in defined mixtures of microbial species, and enables quantitative and reproducible investigation of biological communities.
Matthew E Cockman, Kerstin Lippl ... Peter J Ratcliffe
Assays using recombinant HIF prolyl hydroxylases did not support hydroxylation of more than 20 reported non-HIF substrates under conditions where robust HIF hydroxylation was observed.
Kevin J Forsberg, Ishan V Bhatt ... Harmit S Malik
A high-throughput, activity-based selection identifies many phage-derived inhibitors of Cas9 from human fecal and oral metagenomes, with at least one inhibitor acting via a novel mechanism.