Pengxing Cao, Katharine A Collins ... James M McCaw
A mathematical model of blood-stage infection with Plasmodium falciparum malaria capturing the sexual stage of the parasite life-cycle is validated against human data, providing new insight into human-to-mosquito transmission.
David Massa López, Melanie Thelen ... Markus Damme
The so far uncharacterized lysosomal transporter protein MFSD1 is essential for liver homeostasis and needs the highly glycosylated GLMP protein as an accessory subunit for stability.
Kimberly M Fornace, Neal Alexander ... Chris Drakeley
Local human movement into mosquito habitats around forest edges intensifies interactions between pathogens, insects and people, increasing exposure risks to the zoonotic malaria Plasmodium knowlesi in Malaysian Borneo.
Alfonso Santos-Lopez, Christopher W Marshall ... Vaughn S Cooper
Bacteria growing in biofilms evolve antimicrobial resistance via different pathways and generate greater genetic diversity than well-mixed populations, selecting fitter but less resistant genotypes.
A temperate bacteriophage reprograms the oxygen response of a bacterial signaling system by replacing a host-encoded promoter with a phage-encoded promoter.
People compete by trying to outsmart their opponents as long as they win, but show random behavior, and neural signs of suppressing knowledge about opponents’ strategies, when they lose.
FRET biosensor-based measurement of cAMP signaling and single-channel recording reveal that β-blockers trigger local activation of adrenergic receptors and calcium channels in primary neurons.
The combination of single-cell transcriptomics and whole-brain mapping of bulk and single-cell projections reveals the relationship between the molecular architecture, cell body distribution, and axonal arborization of serotonin neurons.
