Browse our Research Articles

Page 865 of 1,411
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Phage integration alters the respiratory strategy of its host

    Jeffrey N Carey, Erin L Mettert ... Mark Goulian
    A temperate bacteriophage reprograms the oxygen response of a bacterial signaling system by replacing a host-encoded promoter with a phage-encoded promoter.
    1. Neuroscience

    Balancing model-based and memory-free action selection under competitive pressure

    Atsushi Kikumoto, Ulrich Mayr
    People compete by trying to outsmart their opponents as long as they win, but show random behavior, and neural signs of suppressing knowledge about opponents’ strategies, when they lose.
    1. Cell Biology

    β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons

    Ao Shen, Dana Chen ... Yang K Xiang
    FRET biosensor-based measurement of cAMP signaling and single-channel recording reveal that β-blockers trigger local activation of adrenergic receptors and calcium channels in primary neurons.
    1. Neuroscience

    Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

    Jing Ren, Alina Isakova ... Liqun Luo
    The combination of single-cell transcriptomics and whole-brain mapping of bulk and single-cell projections reveals the relationship between the molecular architecture, cell body distribution, and axonal arborization of serotonin neurons.
    1. Microbiology and Infectious Disease

    The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus

    Belinda Baquero-Perez, Agne Antanaviciute ... Adrian Whitehouse
    SND1 has m6A-reading ability and is essential for Kaposi's sarcoma-associated lytic replication.
    1. Biochemistry and Chemical Biology

    Evolutionary and functional insights into the mechanism underlying body-size-related adaptation of mammalian hemoglobin

    Olga Rapp, Ofer Yifrach
    Hemoglobin affinity and cooperativity reveal mechanistic insights in how the relation between physiology and evolutionary variations shape a protein's molecular property.
    1. Developmental Biology

    Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila

    Zong-Heng Wang, Yi Liu ... Hong Xu
    An insulin-Myc feed-forward loop triggered by transient JNK boosts transcription of genes essential for mitochondrial respiration and biogenesis during early oogenesis to support massive mtDNA replication and inheritance in Drosophila.
    1. Physics of Living Systems

    Phylodynamic theory of persistence, extinction and speciation of rapidly adapting pathogens

    Le Yan, Richard A Neher, Boris I Shraiman
    A model of pathogen co-evolving with host population continuously acquiring immunity is used to identify evolutionary parameters allowing pathogen population to persist without going extinct or splitting into independent lineages.
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial fusion is required for spermatogonial differentiation and meiosis

    Grigor Varuzhanyan, Rebecca Rojansky ... David C Chan
    Mitochondrial fusion enables a metabolic transition during spermatogenesis.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells

    Isabelle Maria Blomfield, Brenda Rocamonde ... Noelia Urbán
    Genetic and protein analyses in vitro and in vivo identifies Id4 as a novel regulator of stem cell quiescence in the adult hippocampus.