Browse our Research Articles

Page 866 of 1,524
    1. Cancer Biology

    Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

    Zeyad D Nassar, Chui Yan Mah ... Lisa M Butler
    DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.
    1. Epidemiology and Global Health

    The effect of climate change on yellow fever disease burden in Africa

    Katy AM Gaythorpe, Arran Hamlet ... Neil M Ferguson
    Analysis of yellow fever burden in Africa illustrates the need to consider the effect of a changing climactic conditions when planning future intervention strategies.
    1. Medicine
    2. Neuroscience

    Deciphering the neural signature of human cardiovascular regulation

    Jorge Manuel, Natalia Färber ... Florian Beissner
    At least three hypothalamic subsystems are involved in cardiovascular regulation in humans.
    1. Ecology

    Climate change and intensive land use reduce soil animal biomass via dissimilar pathways

    Rui Yin, Julia Siebert ... Martin Schädler
    Climate change and land-use intensification have negative but largely independent effects on soil animal biomass.
    1. Cancer Biology
    2. Computational and Systems Biology

    Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data

    Simon P Hood, Georgina Cosma ... A Graham Pockley
    Diagnosing the presence and clinical significance of prostate cancer can be achieved using AI-based analysis of peripheral blood natural killer (NK) cell subset profiles.
    1. Neuroscience

    Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

    David Cabañero, Angela Ramírez-López ... Rafael Maldonado
    Operant drug self-administration in a mouse model of neuropathic pain reveals pain-relieving effects of a cannabinoid CB2 receptor agonist that are mediated through CB2 receptors of neurons and lymphocytes.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin

    Charlotte F Kelley, Thomas Litschel ... Naoko Mizuno
    In vitro reconstitution of the core focal adhesion proteins talin and vinculin with actin reveals lipid-dependent release of autoinhibition.
    1. Computational and Systems Biology
    2. Neuroscience

    Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons

    Steven Jack Jerjian, Maneesh Sahani, Alexander Kraskov
    Mirror neurons, including corticospinal neurons, in primary motor cortex of macaque monkeys, clearly dissociate between execution and observation of grasping actions while ventral premotor cortex (F5) maintains a similar representation.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition

    Michael Zavortink, Lauren N Rutt ... Olivia S Rissland
    In fruit flies, maternally deposited RNA-binding proteins are removed during the maternal-to-zygotic transition via a mechanism of translational upregulation of Kondo, the key E2 enzyme, at egg activation.
    1. Immunology and Inflammation

    Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity

    Juan L Mendoza, Suzanne Fischer ... Geraldine M Gillespie
    Potential for specific microbiome-directed, MHC-restricted shaping of a commonly selected HIV-specific CD8+ T cell population was suggested by MHC class I yeast display-based peptide screening approaches.