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Drosophila astrocytes regulate the homeostatic response to sleep need and express the AANAT1 enzyme that limits brain accumulation of serotonin and dopamine caused by overnight sleep deprivation.

A well-trained deep learning neural network can outperform and can potentially assist expertly trained embryologists in selecting embryos based on their implantation potential, even amongst high-quality euploid blastocyst embryos.

Whisker barrels provide clues about neocortical development, as computer modelling shows that barrels can self-organize, based on competition between adjacent thalamocortical axons, suggesting that genetic instruction plays a secondary role.

Neuronal neurofascin takes a surprisingly circuitous route in the neuronal plasma membrane to the axon initial segment where it stabilises ion channel complexes responsible for initiating action potentials.

A region of the Biomphalaria genome, containing highly divergent haplotypes with different combinations of transmembrane genes, strongly impacts whether these snails can transmit parasitic schistosomes.

Cryo-EM reveals that an unexpected domain separation in the zona pellucida module of uromodulin is required for its assembly to filamentous homopolymers that promote pathogen clearance in urinary tract infections.

Identification of PARP1 trapping as the major contributor of PARP1 inhibitor-induced innate immune response.

Individual social behavior results from the interaction between the individuals own oxytocin receptor genotype and the oxytocin receptor genotypes of other individuals present in its social environment.

Individuals with reversed congenital cataracts perceived visual events as occurring earlier than auditory and tactile events revealing that cross-modal temporal biases depend on sensory experience during an early sensitive period.

Erythroid-enriched BMP2K kinase, in addition to its predicted function in endocytosis, regulates distribution and abundance of COPII assemblies and autophagic degradation through opposing actions of its two splicing variants.