Browse our Short Reports

Page 47 of 61
    1. Neuroscience

    Sparse activity of identified dentate granule cells during spatial exploration

    Maria Diamantaki, Markus Frey ... Andrea Burgalossi
    Morphologically-mature granule cells with complex dendritic trees contribute to a sparse representation of space in the rat dentate gyrus.
    1. Neuroscience

    Decreased motor cortex excitability mirrors own hand disembodiment during the rubber hand illusion

    Francesco della Gatta, Francesca Garbarini ... Paola Borroni
    An illusion in which individuals feel that their own hand no longer belongs to them may reflect a temporary reduction in the brain’s ability to control the movement of the hand.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export

    Jian Li, Suzanne R Pfeffer
    LAMP proteins, the major glycoproteins of the lysosome membrane, bind cholesterol directly and specifically, and interact with NPC1 and NPC2 proteins as part of the lysosomal cholesterol export process.
    1. Developmental Biology
    2. Neuroscience

    Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

    Christine J Huh, Bo Zhang ... Andrew S Yoo
    MicroRNA-based direct conversion of human fibroblasts to neurons is applicable to fibroblasts from donors ranging in age from neonatal to centenarian, allowing the generation of neurons that maintain the age-associated signatures of the starting fibroblasts.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

    Paul Capewell, Christelle Cren-Travaillé ... Annette MacLeod
    African trypanosomes residing within the skin of infected humans represent an important yet overlooked transmissible parasite population that may thwart efforts to eliminate African sleeping sickness.
    1. Neuroscience

    NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

    Yo Sasaki, Takashi Nakagawa ... Jeffrey Milbrandt
    Axonal metabolic flux analysis demonstrates that expression of NMNAT1 blocks axonal degeneration in cultured mouse neurons not by altering NAD+ synthesis, but rather by inhibiting injury-induced, SARM1-dependent NAD+ consumption.
    1. Evolutionary Biology

    Phenotypic plasticity as an adaptation to a functional trade-off

    Xiao Yi, Antony M Dean
    A plastic behavior in Escherichia coli is enabled by a single amino acid replacement in adaption to changing environments.
    1. Cell Biology
    2. Developmental Biology

    Wnt proteins can direct planar cell polarity in vertebrate ectoderm

    Chih-Wen Chu, Sergei Y Sokol
    Vertebrate early ectoderm displays planar polarity manifested by a fluorescent sensor and this polarity can be instructed by Wnt ligands.
    1. Cell Biology
    2. Computational and Systems Biology

    Human kinetochores are swivel joints that mediate microtubule attachments

    Chris A Smith, Andrew D McAinsh, Nigel J Burroughs
    The outer domain of the kinetochore can rotate (swivel) around the centromere, and this rather than intra-kinetochore stretching is coupled to anaphase onset.
    1. Neuroscience

    The right hippocampus leads the bilateral integration of gamma-parsed lateralized information

    Nuria Benito, Gonzalo Martín-Vázquez ... Oscar Herreras
    High-resolution electrode recordings reveal left-right asymmetry in hippocampal gamma waves.