Browse our Tools and Resources

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    1. Cell Biology
    2. Developmental Biology

    Single-cell transcriptome analysis of avian neural crest migration reveals signatures of invasion and molecular transitions

    Jason A Morrison, Rebecca McLennan ... Paul M Kulesa
    Single cell transcriptome analysis of an embryonic collective migratory cell population provides new insights into the heterogeneity of transcriptional signatures within a neural crest cell migratory stream.
    1. Neuroscience

    Lifting the veil on the dynamics of neuronal activities evoked by transcranial magnetic stimulation

    Bingshuo Li, Juha P Virtanen ... Alia Benali
    A cellular-level in vivo investigative method that provides unprecedented insights into the dynamics of neuronal activities evoked by transcranial magnetic stimulation.
    1. Cancer Biology
    2. Computational and Systems Biology

    Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

    Julien Racle, Kaat de Jonge ... David Gfeller
    A novel method predicts cancer and immune cell types from bulk tumor gene expression data with the ability to consider uncharacterized and possibly highly variable cell types, which is validated in human genome.
    1. Neuroscience

    Revealing the distribution of transmembrane currents along the dendritic tree of a neuron from extracellular recordings

    Dorottya Cserpán, Domokos Meszéna ... Daniel K Wójcik
    A computational method reveals current sources along the dendritic tree of a single neuron of known morphology from extracellular potential.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

    David R Hill, Sha Huang ... Jason R Spence
    Contact with bacteria and subsequent hypoxia promotes functional maturation of the immature gastrointestinal tract.
    1. Cell Biology

    Time-gated detection of protein-protein interactions with transcriptional readout

    Min Woo Kim, Wenjing Wang ... Alice Y Ting
    A light-dependent two-hybrid tool with transcriptional readout detects multiple protein-protein interactions in living mammalian cells with high signal-to-background ratios and enables genetic selections.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq

    Jason G Dumelie, Samie R Jaffrey
    Genome-wide profiling of R-loops at near single-nucleotide resolution reveals distinct R-loop boundaries depending on the presence and location of the first exon-intron junction.
    1. Cell Biology
    2. Genetics and Genomics

    Rapid re-identification of human samples using portable DNA sequencing

    Sophie Zaaijer, Assaf Gordon ... Yaniv Erlich
    DNA fingerprinting by portable nanopore sequencing is a novel re-identification method with applications in (clinical) laboratories and biobanks.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals

    Inge Kühl, Maria Miranda ... Nils-Göran Larsson
    Comparative -omic analyses of five knockout mouse strains with disrupted mitochondrial DNA expression at different levels provide a high quality resource of altered gene expression patterns that reveal several common secondary patophysiological changes of mitochondrial dysfunction.
    1. Neuroscience

    A versatile genetic tool for post-translational control of gene expression in Drosophila melanogaster

    Sachin Sethi, Jing W Wang
    A chemogenetic tool has been developed to map and manipulate neuronal circuits with spatial and temporal precision.