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Structural reconstruction of thousands of ancient nitrogenases through Earth’s history uncovers architectural constraints that shaped their evolution under global environmental transitions.

The hemogenic gastruloid model of embryonic blood development captures multi-wave haematopoiesis and enables interrogation of infant leukaemia cell-of-origin.

Using Xcr1^Cre-Gfp Rosa26^LSL-DTA Apoe^–/– model and Xcl1^–/– Apoe^–/– mouse model reveal an essential non-redundant role for the XCL1-XCR1 axis in cDC1-mediated atherogenesis.

Cryo-electron tomography reveals plant photosynthetic membranes with single-complex precision, supporting a simple two-domain model of membrane organization.

Visuocortical activity in humans reveals that the spatial focus of covert attention flexibly shifts and expands in accordance with task demands.

New tools for literature mining, such as automated analysis of the research literature, are accessible, scalable, and reliable.

Lymphatic muscle cells, but not CD34⁺ adventitial cells, exhibited pacemaker behaviors including pressure-dependent depolarization, pressure-dependent calcium mobilization during diastole, and propagated contraction waves induced by focal, optogenetic depolarization via channel rhodopsin2.

Primate cross-species analysis of interactions between transposable elements and KRAB-ZNF genes with the new TEKRABber tool highlights human-specific interactions with potential relevance to Alzheimer’s disease.