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Page 206 of 1,800
    1. Cell Biology

    Visualization of endogenous G proteins on endosomes and other organelles

    Wonjo Jang, Kanishka Senarath ... Nevin A Lambert
    Heterotrimeric G proteins are less abundant on endosomes and organelles than on the plasma membrane.
    1. Cell Biology

    Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy

    Mitsuhiro Abe, Masataka Yanagawa ... Yasushi Sako
    The local PI(4,5)P2 nanodomain promotes the dimerization and activation of EGFR in the plasma membrane, whereas activated EGFR dissolves the nanodomain structure of PI(4,5)P2 through PLCγ.
    1. Ecology
    2. Evolutionary Biology

    Neuropeptide Bursicon and its receptor-mediated the transition from summer-form to winter-form of Cacopsylla chinensis

    Zhixian Zhang, Jianying Li ... Songdou Zhang
    Integrated ecological and genetic methods show that Bursicon signaling pathway and miR-6012 regulate the transition from summer-form to winter-form in Cacopsylla chinensis through affecting cuticle pigment and cuticle thickness.
    1. Ecology

    Foxtrot migration and dynamic over-wintering range of an Arctic raptor

    Ivan Pokrovsky, Teja Curk ... Martin Wikelski
    The dynamic over-wintering range of migratory birds, resulting from the newly described 'foxtrot migration' pattern, reveals potential errors in single mid-winter population assessments and highlights implications for their conservation status.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Heparan sulphate binding controls in vivo half-life of the HpARI protein family

    Florent Colomb, Abhishek Jamwal ... Henry J McSorley
    The HpARI family members can either suppress or amplify responses to IL-33, and also differ in their half-life in vivo due to binding to the extracellular matrix constituent, heparan sulphate.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Archaic introgression contributed to shape the adaptive modulation of angiogenesis and cardiovascular traits in human high-altitude populations from the Himalayas

    Giulia Ferraretti, Paolo Abondio ... Marco Sazzini
    A combination of composite-likelihood and gene network-based methods to investigate the impact of Denisovan introgression on the evolution of complex (i.e., polygenic) adaptive traits in high-altitude populations of Tibetan/Sherpa ancestry.
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer

    Nayoung Kim, Sehhoon Park ... Myung-Ju Ahn
    Single-cell RNA sequencing of biopsy samples from advanced-stage lung cancer reveals tumor and immune cell features associated with response to immune checkpoint therapy.
    1. Neuroscience
    2. Computational and Systems Biology

    Adaptive Integration of Perceptual and Reward Information in an Uncertain World

    Prashanti Ganesh, Radoslaw M Cichy ... Rasmus Bruckner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice

    Andres P Varani, Caroline Mailhes-Hamon ... Daniela Popa
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Olfactory cortical outputs recruit and shape distinct brain-wide spatiotemporal networks

    Teng Ma, Xunda Wang ... Alex TL Leong
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing