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    1. Neuroscience

    Dynamic control of sequential retrieval speed in networks with heterogeneous learning rules

    Maxwell Gillett, Nicolas Brunel
    Low-dimensional external inputs are sufficient to control the speed of sequential activity, and to transition between persistent activity, in a network of neurons with both temporally symmetric and asymmetric learning.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

    Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

    Wei-Ping Li, Jia-Ying Su ... Chien-Ling Lin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Medicine

    Different treatment durations of loperamide in preventing pyrotinib-induced diarrhea: A randomized, parallel-group sub-study of the phase II PHAEDRA trial

    Changjun Wang, Yan Lin ... Qiang Sun
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms

    Martin Breyton, Jan Fousek ... Viktor Jirsa
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Stem Cells and Regenerative Medicine

    Epigenetic insights into GABAergic development in Dravet Syndrome iPSC and therapeutic implications

    Jens Schuster, Xi Lu ... Xingqi Chen
    Analyses of epigenetic profiles using ATAC-seq provide a comprehensive investigation of the chromatin landscape in hampered GABAergic differentiation in a DS-patient iPSC-derived disease model.
    1. Medicine

    Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis

    Sindre Lee-Ødegård, Marit Hjorth ... Kåre Inge Birkeland
    Long-term physical exercise had a substantial effect on the plasma proteome, identifying novel exerkines and suggesting CD300LG as a potential link to insulin sensitivity.
    1. Microbiology and Infectious Disease

    Hosts manipulate lifestyle switch and pathogenicity heterogeneity of opportunistic pathogens in the single-cell resolution

    Ziguang Wang, Shuai Li ... Wei Liu
    The host acts as an important factor to control the phenotypic heterogeneity of individual symbionts.
    1. Cancer Biology
    2. Epidemiology and Global Health

    Disentangling the relationship between cancer mortality and COVID-19 in the US

    Chelsea L Hansen, Cécile Viboud, Lone Simonsen
    The competing mortality risk from cancer itself overshadows any increase in COVID-19 mortality risk due to cancer.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Insulator-based dielectrophoresis-assisted separation of insulin secretory vesicles

    Mahta Barekatain, Yameng Liu ... Mark A Hayes
    An unbiased separation method reveals distinct subpopulations of insulin secretory vesicles that undergo dynamic remodeling upon glucose stimulation.
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