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Page 384 of 1,792
    1. Neuroscience

    An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity

    Niraja Ramesh, Marc Escher ... Stephan J Sigrist
    An antagonism between Spinophilin and Syd-1 converge on presynaptic actin to control presynaptic plasticity and memory consolidation in the Drosophila mushroom body.
    1. Neuroscience

    Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement

    Yoshinori Aso, Daichi Yamada ... Toshihide Hige
    A cluster of neurons that integrates inhibitory and excitatory synaptic inputs from the mushroom body output neurons of the appetitive and aversive memory compartments, respectively, triggers upwind steering, mediating memory-driven olfactory navigation behaviors.
    1. Neuroscience

    Bayesian analysis of phase data in EEG and MEG

    Sydney Dimmock, Cian O'Donnell, Conor Houghton
    A Bayesian model of phase angles illustrates a novel approach to the analysis of phase coherence in frequency-tagged experiments.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural foundation for the role of enterococcal PrgB in conjugation, biofilm formation, and virulence

    Wei-Sheng Sun, Lena Lassinantti ... Ronnie P-A Berntsson
    The enterococcal adhesin PrgB consists of four immunoglobulin-like domains that support the proper function of its polymer adhesin domain.
    1. Developmental Biology

    C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy

    Hui Zhang, Chan Li ... Baohua Ma
    In vitro and in vivo data show that C-natriuretic peptide is significant for increasing mitochondrial bioenergetics by cAMP-PKA pathway and improving cytoplasmic and nuclear maturation of maternally aged oocyte.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

    Elliott L Paine, Jack J Skalicky ... Wesley I Sundquist
    Biochemical, structural, imaging, and functional studies reveal how the ESCRT-III protein IST1 recruits the CAPN7 cysteine protease to midbodies, where its proteolytic activity is required for efficient abscission and NoCut checkpoint arrest.
    1. Cancer Biology
    2. Genetics and Genomics

    Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

    Ann-Kathrin Herzfeldt, Marta Puig Gamez ... Lee Kim Swee
    Loss of membrane-bound ICAM-1, overexpression of soluble ICAM-1 or ILKAP activity in tumor cells induce resistance to antigen-specific cytotoxic T-cell-mediated killing independently from regulating antigen presentation, PD-L1 expression, IFN-γ, or TNF-α responsiveness.
    1. Cell Biology

    β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

    Carole Daly, Akim Abdul Guseinov ... Bianca Plouffe
    The vasopressin type 2 receptor promotes dual Gαs and Gαq/11 signaling at early endosomes in β-arrestin-dependent and -independent manners.
    1. Neuroscience
    2. Physics of Living Systems

    Mechanical vibration patterns elicit behavioral transitions and habituation in crawling Drosophila larvae

    Alexander Berne, Tom Zhang ... Mason Klein
    Habituation to mechanical vibration of crawling Drosophila larvae exhibits distinct time constants that characterize desensitization, re-sensitization, and further adaptation to repeated stimulus patterns.