Ifrd1 and Ifrd2 were identified using knockout mice as new molecular players regulating via two discrete mechanisms the activity of the transcriptional regulator Dlk1 and thereby affecting adipocyte differentiation.
Valeria Scagliotti, Maria Lillina Vignola ... Marika Charalambous
Pituitary gland size and stem cell number is modulated during early life in the mouse by the imprinted gene Dlk1, which acts in multiple developmental compartments in a dosage-sensitive manner.
Sana Ahmed-Seghir, Manisha Jalan ... Simon N Powell
Cells exhibit a localized ATR-dependent DNA damage response to a site-specific stalled replication fork that is distinct from that observed after global replication stress.
CD8+ Trm cells' erosion role in oral lichen planus via IFN-γ, TNF-α, and IL17 cytokines has been revealed, addressing a gap in recurrent erosion studies.
A novel animal model of economic decision-making captures complex patterns of choice behavior similar to those of humans, opening the way for mechanistic studies to probe the neural basis for this important form of executive function.
William D Jackson, Chiara Giacomassi ... Marina Botto
A novel pathway of emergency myelopoiesis is induced by repetitive virus stimulation at peripheral barrier sites which bypasses the requirement of conventional pathways and expands myeloid infiltration in tissues.
Two natural tannins, oligomeric proanthocyanidins and punicalagin, acted as potent inhibitors against SARS-CoV-2 infection, and grape seed extract supplementation could serve as a healthy food for infection prevention.
Kia L Davis, Nicole Ackermann ... Vetta L Sanders Thompson
Many people canceled cancer screening and cancer care appointments during the pandemic, but cancer prevention and control practitioners must proactively facilitate their return to care to avoid widening cancer health disparities.
