Browse the latest research

Page 473 of 1,892
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Rapid cloning-free mutagenesis of new SARS-CoV-2 variants using a novel reverse genetics platform

    Enja Tatjana Kipfer, David Hauser ... Thomas Klimkait
    CLEVER enables the rapid manipulation and direct rescue of plus-strand RNA viruses with the shortest hands-on time to study viral variants of concern.
    1. Neuroscience

    The shared and unique neural correlates of personal semantic, general semantic, and episodic memory

    Annick FN Tanguay, Daniela J Palombo ... Louis Renoult
    Four types of declarative memory rely on different weightings of similar component processes, according to fMRI and subjective ratings.
    1. Developmental Biology

    Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration

    Laura Celotto, Fabian Rost ... Michael Brand
    Single-cell transcriptome analysis of the regenerating retina in adult zebrafish reveals molecular control steps during Müller glia stem cell activation, progressive differentiation, and neural regeneration.
    1. Biochemistry and Chemical Biology

    Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2

    Kehan Chen, Lie Wang ... Gang Wu
    Six-transmembrane epithelial antigen of the prostate isoform 1 (STEAP1) can establish a physiologically relevant electron transfer chain and STEAP2 can transfer electrons via a diffusible FAD mechanism.
    1. Neuroscience

    Single-cell RNAseq analysis of spinal locomotor circuitry in larval zebrafish

    Jimmy J Kelly, Hua Wen, Paul Brehm
    Single-cell transcriptomics of larval zebrafish spinal cord reveal ion channels and exocytotic machinery that enhance transmitter release in neuronal types shown to mediate high-speed swimming and escape behavior.
    1. Chromosomes and Gene Expression

    What AlphaFold tells us about cohesin’s retention on and release from chromosomes

    Kim A Nasmyth, Byung-Gil Lee ... Jan Löwe
    Structural predictions using AlphaFold suggest a mechanism by which Wapl mediates cohesin's dissociation from chromatin, a process whose downregulation is essential for VDJ recombination and diverse protocadherin gene expression.
    1. Neuroscience

    Judging the difficulty of perceptual decisions

    Anne Löffler, Ariel Zylberberg ... Daniel M Wolpert
    Deciding which of two perceptual decisions is more difficult involves sequential sampling processes that terminate when the difference in accumulated evidence for each decision exceeds a threshold.
    1. Neuroscience

    Selective transduction and photoinhibition of pre-Bötzinger complex neurons that project to the facial nucleus in rats affects nasofacial activity

    Mariana R Melo, Alexander D Wykes ... Andrew M Allen
    The pre-Bötzinger complex, known as the kernel for the breathing generation, consists of separate subpopulations of neurons that project to specific nuclei to coordinate respiratory rhythmicity with different physiological behaviors, such as nasofacial activity.
    1. Cell Biology

    Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability

    Ke Lu, Ming Zhang ... Di Chen
    Cyclin D1 protein stability is regulated by ubiquitin-proteasome mechanism mediated by multiple E3 ligases, including newly identified Keap1, DDB2, and WSB2.