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A human pluripotent stem cell-based model demonstrates how TP53/RB1 loss and MYC overexpression drive aggressive, neuroendocrine small cell lung cancer progression and metastasis, enabling investigation of tumor heterogeneity and therapeutic response in a defined genetic context.

A genome-wide association study identifies 291 candidate genes for diapause and implicates olfactory pathway genes and cells in the regulation of this adaptive dormancy program in Drosophila.

Reaction-diffusion network modeling unveils general design principles that both stabilize cell polarization patterns and enable tunable interface localization, reconciling extensive experimental observations and deepening the understanding of asymmetric cell division.

Systemic neutrophils do not respond to laser-induced photoreceptor damage despite the robust response from resident microglia.

Gliding multicellular cyanobacteria results from cellular coordination, the loss of which results in the collapse of orderly back-and-forth movement of filaments and in filament buckling.

Cochlear neural degeneration in middle-aged adults with normal-hearing thresholds is associated with increased listening effort and behavioral deficits in challenging acoustic environments.

A modular DNA barcoding strategy enables efficient multiplexed protein detection for both in situ imaging and high-throughput molecular diagnostics.

Engraved features found within the Dinaledi Subsystem are interpreted as being made by Homo naledi in the absence of evidence of other candidate makers.