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    1. Neuroscience

    Identification of novel human microcephaly-linked protein Mtss2 that mediates cortical progenitor cell division and corticogenesis through Nedd9-RhoA

    Aurelie Carabalona, Henna Kallo ... Claudio Rivera
    ABBA ensures proper cortical development by regulating radial glial division through RhoA activity at the cleavage furrow, and its mutation results in developmental abnormalities linked to microcephaly.
    1. Immunology and Inflammation

    A dual nature of γδ T cell immune memory responses

    Tsz Kin Suen, Burcu Al ... Katarzyna Placek
    Both adaptive and innate immune memory responses have been described in gamma delta T cells, yet the mechanisms, the ligands and the gamma delta T cell subsets generating memory responses have remain to be explored.
    1. Neuroscience

    Sexual failure decreases sweet taste perception in male Drosophila via dopaminergic signaling

    Gaohang Wang, Wei Qi ... Liming Wang
    Failure in sexual behaviors suppresses sweet taste perception of male fruit flies, by dampening dopaminergic signaling between mating-related neural circuits and peripheral gustatory pathways.
    1. Cell Biology

    Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors

    Dongyue Jiao, Kun Chang ... Chenji Wang
    Disrupting WSB2-mediated NOXA degradation sensitizes cancer cells to apoptosis and provides a new strategy to overcome resistance to BCL-2 inhibition.
    1. Immunology and Inflammation

    Bioengineering approaches to trained immunity: Physiologic targets and therapeutic strategies

    Hannah Riley Knight, Marie Kim ... Aaron Esser-Kahn
    Current approaches in bioengineering are synthesized and methods for their implementation are suggested for the induction and modulation of trained immunity in the treatment of human diseases.
    1. Cancer Biology

    Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing

    Einav Somech, Debdatta Halder ... Itay Tirosh
    SiNETs separate into two subtypes, both with low proliferation of neuroendocrine cells and higher proliferation of other cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stochastic cell-intrinsic stem cell decisions control colony growth in planarians

    Tamar Frankovits, Prakash Varkey Cherian ... Omri Wurtzel
    Stochastic intrinsic fate decisions by planarian stem cells drive clonal expansion and reveal a straightforward, feedback‐independent mechanism for robust cell identity selection.
    1. Developmental Biology
    2. Neuroscience

    Microtubule networks in zebrafish hair cells facilitate presynapse transport and fusion during development

    Saman Hussain, Katherine Pinter ... Katie S Kindt
    Formation of specialized ribbon synapses in sensory hair cells involves dynamic precursor movement, microtubule-guided transport, and precursor fusion, culminating in synapse assembly essential for hearing and balance.
    1. Neuroscience
    2. Evolutionary Biology

    Investments in photoreceptors compete with investments in optics to determine eye design

    Francisco JH Heras, Simon B Laughlin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Synaptic Encoding of Time in Working Memory

    Gianluigi Mongillo, Misha Tsodyks
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete