Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Developmental Biology

   NAD boosting mediated by CD38 inhibition drives reversal of a pathological vicious cycle of intracrine activity and inflammation in eyelid meibomian gland dysfunction

   Yuki Hamada, Takehide Sakamoto ... Masao Doi
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Kinesin-1 holoenzyme assembly coordinates cargo-adaptor recognition with heavy-chain autoinhibition

   Jingling Niu, Mengmeng Zhang ... Chao Wang
3. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer

   Qian Wang, Liping Li ... Chuo Chen

   Catalytic inhibition of tankyrase induces tankyrase accumulation and rigidifies the β-catenin destruction complex, limiting its ability to suppress WNT signaling.
4. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

   Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden

   Examining the metabolic response of cancer cells to nutrient depletion reveals how the cell NAD+/NADH ratio can determine what nutrient environments are compatible with cancer cell proliferation.
5. 1. Biochemistry and Chemical Biology

   Inhibiting the interaction between the mitochondrial receptor Tom70 and SARS CoV 2 Orf9b with small molecules

   CJ San Felipe, Kliment A Verba ... James S Fraser
6. 1. Biochemistry and Chemical Biology

   Glycolipid MPIase is essential for the TAT (twin-arginine translocation) pathway

   Hanako Nishikawa, Nachi Yamamoto ... Ken-ichi Nishiyama

   The glycolipid MPIase acts as a receptor of twin-arginine translocation (TAT) signals, inserts them into membranes, and potentially modulates the TatABC structure to facilitate TAT translocation.
7. 1. Biochemistry and Chemical Biology

   Lateral opening site of human oligopeptide transporter 2 plays a key role in the interaction with polymyxins

   Xukai Jiang, Yining Luo ... Jian Li

   Mapping the molecular interactions between polymyxins and hPepT2 enables rational design of safer lipopeptide antibiotics with reduced renal toxicity while retaining antibacterial activity.
8. 1. Biochemistry and Chemical Biology

   D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport

   Masataka Suzuki, Kenichiro Adachi ... Jumpei Sasabe
9. 1. Biochemistry and Chemical Biology

   Cell cycle-coupled CK1δ turnover, autoinhibition, and activity

   Fidel Emmanuel Serrano, Bianca Ruppert ... Michael Brunner

   In light of recent observations of how CK1δ is dynamically regulated, kinase activity and abundance are also regulated throughout the cell cycle primarily through phosphorylation at the C-terminal tail.
10. 1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

    Bas de Boer, Thomas D Lamme ... Christopher T Schafer