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Latest articles

1. 1. Neuroscience

   Neurodevelopmental Disorders: Unraveling the impact of genetic variants

   Bruce Herring

   Experiments in mice reveal how three rare mutations in a gene called TRIO can lead to different neurodevelopmental outcomes.
2. 1. Immunology and Inflammation

   Interferon Signaling: Immobilizing bacteria to prevent infections

   Patricia Reist Iscar, Petr Broz

   The interferon-induced GTPase GVIN1 prevents bacteria from spreading among cells by coating them and rendering them immobile.
3. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Cell Surface Receptors: Virus attacks fish by muscling its way into cells

   Ping-Ping Liu, Zhe Wei, Xian-Wei Wang

   Nervous necrosis virus typically enters host cells via endocytosis, but it can also enter via a process called macropinocytosis.
4. 1. Microbiology and Infectious Disease

   Helicase Loading: A back-up mechanism for replication

   Godefroid Charbon, Anders Løbner-Olesen

   A protein called PriC allows DNA replication to proceed in Escherichia coli when the complex that usually initiates this process is compromised.
5. 1. Neuroscience

   Consciousness: Did you see it?

   Ling Liu

   Cautious reporting choices can artificially enhance how well analyses of brain activity reflect conscious and unconscious experiences, making distinguishing between the two more challenging.
6. 1. Cell Biology
   2. Neuroscience

   Vision: A pathway to sight

   Katherine J Wert

   The breakdown of glutamine is an important metabolic pathway for the health and survival of rod photoreceptors within the retina.
7. 1. Neuroscience

   Synaptic Plasticity: A new mode of action for unconventional NMDA receptors

   Ikuko Smith

   Presynaptic NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role.
8. 1. Genetics and Genomics
   2. Neuroscience

   Pain: Epidermal cells and sensory neurons team up

   Jean-Christophe Boivin, Tomoko Ohyama

   Experiments in fruit fly larvae show that epidermal cells can communicate with sensory neurons to drive responses to pain.
9. 1. Chromosomes and Gene Expression

   Gene Regulation: Linking O-GlcNAc and intron retention

   John A Hanover

   An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.
10. 1. Cell Biology
    2. Developmental Biology

    Cell Signaling: Not all dimers are equal

    Jeet H Patel, Mary C Mullins

    Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.