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Latest articles

1. 1. Cancer Biology

   Breast Cancer: Slowing the growth of drug-resistant tumors

   Yingyi Zhang, Qianying Lu

   Using drugs that inhibit enzymes called CDK4/6 and CDK2 extends the G1 phase of the cell cycle and helps to slow the growth of drug-resistant breast cancer.
2. 1. Neuroscience

   Experience-Dependent Plasticity: The little brain supervises learning in the big brain

   Martha Garcia, Mark Wagner

   Experiments on mice reveal how the cerebellum modulates plasticity in the somatosensory cortex.
3. 1. Microbiology and Infectious Disease

   Tuberculosis: A surprising new hiding place for a dangerous pathogen

   Sheetal Gandotra, Yogendra Singh

   The bacterium that causes TB can hide in liver cells called hepatocytes, and reprogram their metabolism for its own benefit.
4. 1. Neuroscience

   Neuronal Activity: Keeping track of moving targets

   Renata Batista-Brito, Geoffrey Terral

   A new method for tracking the activity of individual neurons day after day in the growing brain has revealed a key developmental transition in neuronal activity.
5. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Metabolism: How one nutrient controls cell size

   Angela Montero, Lydia WS Finley

   The metabolic fate of a nutrient called pyruvate determines how big cells become.
6. 1. Genetics and Genomics

   Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

   Lesley T MacNeil

   Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Bacteriology: How Shigella tackles host defences

   Yizhou Huang, Teresa LM Thurston

   The pathogenic bacteria Shigella avoids detection inside hosts cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.
8. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Chromosomes: Exploring a crossroads in the aging process

   Kiyan Shabestary, Daniel E Gottschling

   Experiments on yeast show that the nuclear pore complex has a central role in the loss of chromosomes associated with aging.
9. 1. Neuroscience

   Neuronal Migration: How hunger guides new brain cells to their destination

   Fang-Shin Nian, Laurent Nguyen

   Blood flow and a hormone called ghrelin help new neurons travel to where they are meant to be in the brain of adult mice.
10. 1. Neuroscience

    Primate Research: Probing the staying power of chemogenetics

    Maria Puchik, Igor Kagan

    A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of nonhuman primates.