Insights

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Drug Discovery: How to exploit the recycling system of a cell

   Sasha L Evans, Bethany A Haynes ... Rivka L Isaacson

   Nature has inspired the design of improved inhibitors for cancer-causing proteins.
2. 1. Cell Biology

   Beta Cells: Opportunity makes a hub or a leader

   Marjan Slak Rupnik

   Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.
3. 1. Evolutionary Biology
   2. Neuroscience

   Vision: The inner workings of a miniature eye

   Gregor Belušič

   The first complete 3D reconstruction of the compound eye of a minute wasp species sheds light on the nuts and bolts of size reduction.
4. 1. Neuroscience

   Pain-Related Memory Impairment: How does chronic pain lead to memory loss?

   Suelen Pereira, Ivan Tomsic ... Mychael V Lourenco

   A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.
5. 1. Neuroscience

   Opioids: Finding new ways to treat overdoses

   Jill R Turner, Jocelyn Martin

   Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.
6. 1. Genetics and Genomics

   Down Syndrome: How a gene fuels ear infections

   Sedigheh Delmaghani, Aziz El-Amraoui

   The DYRK1A enzyme is a pivotal contributor to frequent and severe episodes of otitis media in Down syndrome, positioning it as a promising target for therapeutic interventions.
7. 1. Chromosomes and Gene Expression

   Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules

   Carlos Moreno-Yruela, Beat Fierz

   Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.
8. 1. Cell Biology

   Aging: Restoring bone healing potential

   Inês Sequeira

   A combination of intermittent fasting and administering Wnt3a proteins to a bone injury can rejuvenate bone repair in aged mice.
9. 1. Developmental Biology

   Brain Development: Single cells tell it all

   Margaret Hines, Elias Oxman ... Irene Zohn

   A new single-cell atlas of gene expression provides insights into the patterning of the neural plate of mice.
10. 1. Computational and Systems Biology

    Cellular Respiration: Mapping mitochondrial aging

    Alessandro Bitto

    Measuring mitochondrial respiration in frozen tissue samples provides the first comprehensive atlas of how aging affects mitochondrial function in mice.