Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Profiling endogenous Bruchpilot proteins in multiple cell types in mushroom bodies uncovered multilayered spatial configurations of active zones, from stereotyped intracellular distribution patterns to local arrangements of neighboring synapses.
Functional connectivity reveals brain attractors that match predictions of free‑energy‑minimizing attractor theory, yielding an interpretable generative model of brain dynamics in rest, task, and disease.
At birth, infant visual cortex connectivity resembles that of blind adults, while lifetime visual experience enhances long-range functional connectivity between visual cortices, sensorimotor systems, and dampens connectivity with executive networks.
Mycobacterium tuberculosis utilizes nucleomodulins to disrupt host inflammatory responses and lysosomal maturation, uncovering a novel strategy for immune evasion and intracellular survival.
Manuel Dominguez-Rodrigo, Enrique Baquedano ... Audax Mabulla
The discovery of the earliest direct evidence of systematic proboscidean butchery at Olduvai Gorge demonstrates that by 1.8 Ma early hominins had strategically integrated megafaunal exploitation into their subsistence systems.
Philip MM Ruppert, Aylin S Gueller ... Jan-Wilhelm Kornfeld
Transcriptomic profiling on liver and adipose depots reveals tissue-specific and beige-fat–convergent responses to methionine restriction and cold, providing a high-quality resource to guide combinatorial lifestyle interventions for metabolic disease research.
Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
