Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
RadD recognition by NKp46 converts Fusobacterium nucleatum from an immune-evasive pathogen into a trigger of natural killer cell-mediated tumor control in a context-dependent manner.
Residual plasma from rapid routine clinical chemistry tubes enables cell-free DNA NGS-based analysis, providing an untapped, scalable, and accessible resource without specialized collection workflows.
Chengcheng Fan, Alexander A Cohen ... Magnus AG Hoffmann
Bivalent EABR mRNA boosters broaden neutralizing responses to Omicron subvariants by promoting diverse receptor-binding domain epitope targeting, although antibody responses remain partially shaped by immune imprinting from prior vaccination.
An on-demand seizure model in chronically epileptic mice integrates reliability and etiological relevance, providing a mechanistically grounded, efficient platform for evaluating pharmacological interventions.
During convergent extension morphogenesis, non-canonical Wnt induces the signal transducer Dishevelled to transition from Vangl to Frizzled, a process that is inhibited by Prickle but facilitated by the co-receptor Ror.
Single-cell and bulk lineage tracing reveals that adult bone marrow endothelial cells generate functional hematopoietic progenitor and mature blood cells, expanding the cell sources of postnatal hematopoiesis.
Computer simulations reveal the structural basis for a selective mechanism of ion-channel inhibition that could guide future pharmacological developments against associated human health disorders.
The thermosensory neuron AFD unexpectedly modulates locomotion based on tactile experience through molecular and circuit mechanisms distinct from those underlying thermosensation.
