Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Immunology and Inflammation

    Deciphering interferon functions in avian influenza using receptor knockout models in the natural host

    Mohanned Naif Alhussien, Hanna Kaisa Vikkula ... Benjamin Schusser
    Interferon receptor knockout chickens uncover how type I and III interferons differentially shape avian antiviral immunity and influenza disease outcomes.
    1. Neuroscience

    Disinformation elicits learning biases

    Juan Vidal-Perez, Raymond J Dolan, Rani Moran
    Learning from potential disinformation introduces specific cognitive biases, causing individuals to systematically deviate from an idealized Bayesian updating strategy.
    1. Structural Biology and Molecular Biophysics

    Conformational variability of HIV-1 Env trimer and viral vulnerability

    Yiwei Cao, Wonpil Im
    Large-scale all-atom simulations of a full-length, glycosylated HIV-1 Env trimer in an asymmetric membrane reveal a rigid ectodomain and highly diverse conformational landscapes in the membrane-proximal region and transmembrane domain.
    1. Medicine

    Differential regulation of hepatic macrophage fate by Chi3l1 in metabolic dysfunction-associated steatotic liver disease

    Jia He, Bo Chen ... Zhao Shan
    Chi3l1 binding to glucose protects Kupffer cells and limits MASLD progression.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Estimating probabilities of malaria importation in southern Mozambique through modelling P. falciparum genomics and mobility patterns

    Arnau Pujol, Arlindo Chidimatembue ... Alfredo Mayor
    Malaria importation in Matutuine district from southern Mozambique is strongly contributing to sustaining transmission, with Inhambane province being the main source of importation.
    1. Physics of Living Systems

    Controlling the synchronization and symmetry breaking of coupled bacterial pili on active biofilm carpets

    Baha Altın, Enes Talha Günay ... Askin Kocabas
    Active biofilm carpets generate Mexican-wave-like synchronized dynamics and topological defects through nonreciprocal pili interactions.
    1. Microbiology and Infectious Disease

    Mycobacterium tuberculosis partitions the Krebs cycle under iron starvation

    Agnese Serafini, Acely Garza-Garcia ... Riccardo Manganelli
    Mycobacterium tuberculosis rewires central carbon metabolism to circumvent iron-dependent metabolic routes during iron starvation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the recruitment of viral type 2 IRES to ribosomal preinitiation complex for protein synthesis

    Deepakash Das, Tanweer Hussain
    The viral type 2 internal ribosome entry site uses a unique mechanism to hijack the host ribosomal machinery by interacting with initiator tRNA and 40S head.
    1. Neuroscience

    Intrinsic properties link a network model to zebra finch song

    Nelson D Medina, Dan Margoliash
    Whole-cell recordings paired with a network model show that post-inhibitory rebound excitation in premotor neurons couples intrinsic excitability to the temporal structure of learned birdsong.
    1. Cell Biology

    PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression

    Jimena Druker, Hao Jiang ... Angus I Lamond
    Proline hydroxylation of RepoMan (CDCA2) at P604 by PHD1 is shown to be important for mitotic progression and regulating interaction with PP2A regulatory subunit B56 gamma.