Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Philip MM Ruppert, Aylin S Gueller ... Jan-Wilhelm Kornfeld
Transcriptomic profiling on liver and adipose depots reveals tissue-specific and beige-fat–convergent responses to methionine restriction and cold, providing a high-quality resource to guide combinatorial lifestyle interventions for metabolic disease research.
Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
Antoine Bouyeure, Daniel Pacheco-Estefan ... Nikolai Axmacher
Fear updating relies on a flexible shift from generalized to item-specific, context-bound neural representations, revealing how the brain adapts to changing threat contingencies and why fear can return.
The human posterior inferotemporal cortex integrates endogenous and exogenous influences to form a unified attentional priority map for adaptive visual control.
Self-related information automatically modulates early attentional selection into awareness through mechanisms distinct from physical salience, revealing an obligatory, individualized self-prioritization at the gateway to perception.
In statistical fine-mapping, signals stable across stratified subgroups can capture functionally important loci missed by covariate adjustment approaches, and prioritizing agreement between both approaches enhances functional variant discovery.
Anisa Azatovna Gumerova, Georgii Pevnev ... Vitaly Ryu
Using RNAscope mapping provides the comprehensive, sex-specific atlas of vasopressin and its receptor gene expression across the murine brain, refining understanding of how vasopressin signaling is anatomically organized to regulate social behavior, stress responsivity, and homeostasis.
Anurag A Agrawal, Amy P Hastings, Paola Rubiano-Buitrago
Confirming coevolutionary theory, monarch butterfly caterpillars show impaired growth and toxin sequestration when feeding on realistic cardenolide mixtures from their milkweed host plants.
Evidence is provided suggesting that aggregate neural activity at an early stage of visual processing (V1) can directly contribute to perceptual decisions in humans.
