Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Francisco Muñoz-Carvajal, Nicole Sanhueza ... Felipe A Court
Age-related epigenetic regulation of mitochondrial stress responses drives neuronal degeneration and sensory decline, highlighting mitochondrial resilience as a potential target to preserve brain function during aging.
Modeling approaches demonstrate utility for incidence and reproductive number prediction and have potential to complement traditional surveillance in real time to guide public health interventions.
Humans’ flexible temporal cognition, including mental time travel, arises from perspective-agnostic encoding of event sequences in the hippocampus and perspective-dependent retrieval and reconstruction in the posterior parietal cortex.
The Mettl5/Trmt112 complex alters rRNA methylation, increasing PERIOD protein linking ribosome function, clock genes, and proteasome in sleep regulation in Drosophila.
David Ocampo, Carlos Daniel Cadena ... Gustavo A Londoño
In Neotropical birds, eggshells show that water vapor conductance declines with elevation, but structural responses vary across species, suggesting no single underlying mechanism and highlighting the need to further evaluate eggshell traits as determinants of elevational limits.
A high-resolution 3D imaging platform reveals the periportal lamellar complex as a novel structural feature in the mouse liver, regulating bile duct and nerve migration during fibrosis.
High levels of circulating estradiol enable the RP3V kisspeptin neuron population to exhibit long-lasting synchronized oscillatory behavior that drives GnRH neurons to initiate the LH surge.
The first all-atom models of the mycobacterial outer membrane reveal how lipid organization and asymmetry generate a structurally heterogeneous barrier that underlies its unique permeability properties.
A fully computationally designed SaCas9 variant expands PAM recognition to NNNRRT, achieving up to 116-fold higher editing at noncanonical sites while matching the performance of experimentally evolved variants.
Continuous flash suppression reduces V1 orientation responses in an ocular-dominance-dependent manner, which may still allow low-level coarse orientation discrimination but provide insufficient information for higher-level visual and cognitive tasks.
