Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Neural reward signals following effort are amplified for self-benefiting outcomes but attenuated for other-benefiting outcomes, contingent upon reward magnitude and individual effort sensitivity.
Elena Badillo Goicoechea, Phillip F Agres ... Joel L Voss
Meta-analysis indicates that network-targeted non-invasive brain stimulation consistently enhances memory function supported by the hippocampal network, thus providing robust evidence that specific memory abilities rely on specific modifiable brain networks.
A newly developed chemo-immunological strategy enabled detection of acetoacetate-mediated lysine acetoacetylation, identified the associated regulatory enzymes, and revealed its distinct biological functions and physiological significance.
Dissociable neural signatures of integration and segregation provide the first direct neuroimaging evidence for the integration-segregation theory of exogenous attention.
Intravital microscopy of meningeal macrophage Ca²⁺ dynamics reveals previously unknown population heterogeneity, vasomotion-coupled activity, and diverse responses during steady state and neuroinflammatory conditions, offering relevant insights into brain immune regulation.
Mahdiyar Shahbazi, Olivier Codol ... Paul L Gribble
Recurrent neural network models trained on a novel motor skill exhibit a persistent shift in preparatory activity that enables faster relearning, without cognitive or contextual cues.
Mofida Abdelmageed, Premkumar Palanisamy ... Anirban Paul
Progressive DNA polymerase kappa relocalization in aging neurons associates with increased DNA damage and identifies a novel cell type- and activity-dependent role in neuronal genome maintenance.
The Drosophila ryanodine receptor plays a conserved role in setting functional and structural muscle properties, regulates embryonic muscle development and could be used to assess the impact of human RYR1 mutations.
