Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Endogenous corazonin signaling modulates the post-mating switch in behavior and physiology in females of the brown planthopper and Drosophila

    Ning Zhang, Shao-Cong Su ... Shun-Fan Wu
    Endogenous corazonin signaling is a conserved female-driven regulator of the post-mating response in insects.
    1. Neuroscience

    Cortical motor activity modulates respiration and reduces apnoea in neonates

    Coen S Zandvoort, Fatima Usman ... Caroline Hartley
    Communication between the cortex and respiration, known as cortico-respiratory coupling, occurs in newborn infants and relates to apnoea rate.
    1. Immunology and Inflammation

    HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane

    Adriana Quijada-Freire, César A Santiago ... Mario Mellado
    HIV-1 remodels the spatial organization of its co-receptor, CXCR4, on T cell membranes, showing that viral entry requires receptor clustering rather than simple receptor binding.
    1. Ecology
    2. Neuroscience

    Drift in individual behavioral phenotype as a strategy for unpredictable worlds

    Ryan T Maloney, Athena Q Ye ... Benjamin L de Bivort
    Individual flies have idiosyncratic preferences that shift over their lifetime in a way that depends on genotype and may be adaptive to rapidly changing environmental pressures.
    1. Neuroscience

    Regime shift detection and neurocomputational substrates for under and overreactions to change

    Mu-Chen Wang, George Wu, Shih-Wei Wu
    In a stylized regime-shift detection task, human fMRI evidence shows that under- and overreactions to change arise from dissociable contributions of the frontoparietal network and ventromedial prefrontal cortex.
    1. Neuroscience

    Cross-modal interaction of human alpha activity does not reflect inhibition of early sensory processing in a frequency-tagging study using EEG and MEG

    Marion Brickwedde, Rupali Limachya ... Ali Mazaheri
    Early visual alpha oscillations correlate on a trial-by-trial basis with steady-state responses at later stages of the processing stream, implying a role in signal enhancement and interareal communication.
    1. Evolutionary Biology

    Recombination shapes the diversification of the wtf meiotic drivers

    Yan Wang, Hao Xu ... Guan-Zhu Han
    wtf genes, a poison-antidote meiotic driver, underwent recurrent and intricate recombination, which likely generates new meiotic drivers.
    1. Cell Biology
    2. Neuroscience

    Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila

    Francisco Muñoz-Carvajal, Nicole Sanhueza ... Felipe A Court
    Age-related epigenetic regulation of mitochondrial stress responses drives neuronal degeneration and sensory decline, highlighting mitochondrial resilience as a potential target to preserve brain function during aging.
    1. Epidemiology and Global Health

    Prediction of SARS-CoV-2 transmission dynamics based on population-level cycle threshold values: An epidemic transmission and machine learning modeling study

    Afraz Arif Khan, Hind Sbihi ... Catherine A Hogan
    Modeling approaches demonstrate utility for incidence and reproductive number prediction and have potential to complement traditional surveillance in real time to guide public health interventions.
    1. Neuroscience

    Neural representation of time across complementary reference frames

    Yangwen Xu, Nicola Sartorato ... Roberto Bottini
    Humans’ flexible temporal cognition, including mental time travel, arises from perspective-agnostic encoding of event sequences in the hippocampus and perspective-dependent retrieval and reconstruction in the posterior parietal cortex.