Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson
Design and integration of various biomolecular sensors for over-activated rat sarcoma (RAS) created synthetic gene circuits that distinguish mutant versus wild-type signaling and express a therapeutic protein to kill RAS-driven cancer cells.
Lauri Nurminen, Maryam Bijanzadeh, Alessandra Angelucci
The trial-to-trial variability of neuronal responses and the correlated response variability among neurons are modulated by visual stimulus size in a manner that depends on cortical layer, suggesting multiple circuits and mechanisms as the source of variability.
Saccades selectively disrupt spatial but not colour memory, and while transsaccadic updating remains resilient to ageing and neurodegeneration, individual drawing deficits arise from impaired initial encoding and memory decay.
A multivariate analysis of electroencephalography activity reveals super-additive enhancements to the neural encoding of audiovisual stimuli, providing new insights into how the brain integrates multisensory information to optimise spatial localisation.
High-throughput measurement of neutralization titers using a new sequencing-based assay can help explain which seasonal influenza strains spread in the human population.
Giuseppina R Briola, Mohammad Tehseen ... Alfredo De Biasio
Human CTF18–RFC employs a unique structural stabilization mechanism to optimize PCNA loading and stimulate DNA synthesis by the leading-strand polymerase.
During the acquisition of correct rejection response, rankings of functional connection separated for cortical and subcortical regions, which is predictive of the peak timing of visual information encoding across the network.
Camille Elleaume, Bruno Hebling Vieira ... Nicolas Langer
Systematic analyses show that normative model performance strongly depends on sample size and covariate distributions, larger samples yield more stable fits, while misaligned covariates introduce systematic distortions in predictions.
Maximilian C Pöverlein, Alexander Jussupow ... Ville RI Kaila
Respiratory supercomplex formation relieves molecular strain of mitochondrial membranes and reshapes global protein motions, linking membrane reorganization to respiratory function.
Gender differences in submission behavior, driven by self-perceptions of novelty and peer discouragement, limit women’s representation in high-impact journals and, in turn, their scientific visibility and career advancement.
