Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Evolutionary Biology
    2. Neuroscience

    Toward neuroanatomical and cognitive foundations of macaque social tolerance grades

    Sarah Silvere, Julien Lamy ... Sebastien Ballesta
    Macaque’s social tolerance grades, through its underlying cognitive demands, shape subcortical structures volumes.
    1. Medicine

    Sperm motility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

    Charline Vilpreux, Paul Fourquin ... Jessica Escoffier
    Naked mRNA administration in the testes rescues sperm function, demonstrating a potential therapeutic approach for genetic male infertility.
    1. Neuroscience

    Dissociable dynamic effects of expectation during statistical learning

    Hannah H McDermott, Federico de Martino ... Ryszard Auksztulewicz
    Neural responses during statistical learning reveal dissociable dynamic effects of expectation, supporting the opposing process theory within trials while demonstrating contrasting effects across trials.
    1. Computational and Systems Biology
    2. Ecology

    Agent-based modeling reveals how bats navigate dense group emergences

    Omer Mazar, Yossi Yovel
    Acoustic jamming during bat emergence is weaker than expected because signal redundancy, echo integration, and simple movement rules enable robust navigation, as demonstrated by an agent‑based sensory-motor model.
    1. Computational and Systems Biology

    Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data

    Guangzhao Cheng, Aki Vehtari, Lu Cheng
    SegPore refines raw signal segmentation and alignment in nanopore direct RNA sequencing and thereby boosts the performance of RNA modification detection from in vitro data at single-read resolution.
    1. Ecology
    2. Epidemiology and Global Health

    Rift Valley fever virus dynamics in a transhumant cattle system in The Gambia

    Essa Jarra, Divine Ekwem ... Daniel T Haydon
    Endemic Rift Valley fever virus circulation in The Gambia is driven by seasonal cattle movements and eco-region differences, highlighting livestock mobility as a key target for effective control strategies.
    1. Developmental Biology

    Genetic network shaping Kenyon cell identity and function in Drosophila mushroom bodies

    Pei-Chi Chung, Kai-Yuan Ku ... Hung-Hsiang Yu
    The genetic network of BTB zinc finger transcription factors and Eip93F is crucial for Kenyon cell identity regulation and neuronal function acquisition in the construction of Drosophila mushroom bodies.
    1. Neuroscience

    Flexible neural representations of abstract structural knowledge in the human entorhinal cortex

    Shirley Mark, Philipp Schwartenbeck ... Timothy E Behrens
    A novel fMRI method reveals that humans generalize task structure across non-aligned state spaces, showing entorhinal representations support flexible knowledge transfer.
    1. Neuroscience

    Transsaccadic working memory in healthy ageing and neurodegenerative disease

    Sijia Zhao, Thomas Parr ... Masud Husain
    Saccades selectively disrupt spatial but not colour memory, and while transsaccadic updating remains resilient to ageing and neurodegeneration, individual drawing deficits arise from impaired initial encoding and memory decay.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson
    Design and integration of various biomolecular sensors for over-activated rat sarcoma (RAS) created synthetic gene circuits that distinguish mutant versus wild-type signaling and express a therapeutic protein to kill RAS-driven cancer cells.