Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Replication origins in Trypanosoma brucei integrate multiple features previously described individually in opisthokonts, revealing a unified structural topology built from strand-specific nucleotide composition, G‑quadruplex enrichment, and distinctive nucleosome patterns.
Addictive drugs, as well as ketamine/xylazine, change the connectivity to ventral tegmental area dopamine cells, which may be related to cellular activity.
Drosophila female germline tumors mutant for bam or bgcn mimic the stem cell niche to inhibit the differentiation of neighboring wild-type germline stem cells.
Exposure of human cortical interneurons to hypoxia leads to decreased migration, a process that is likely altered in preterm infants and contributes to the increased risk for neurodevelopmental problems.
Biochemical and genetic evidence identifies ATP5I as a biguanide target, redefining biguanide action through ATP synthase regulation and assembly, mitochondrial architecture, and mitochondrial protein turnover.
Neural reward signals following effort are amplified for self-benefiting outcomes but attenuated for other-benefiting outcomes, contingent upon reward magnitude and individual effort sensitivity.
Elena Badillo Goicoechea, Phillip F Agres ... Joel L Voss
Meta-analysis indicates that network-targeted non-invasive brain stimulation consistently enhances memory function supported by the hippocampal network, thus providing robust evidence that specific memory abilities rely on specific modifiable brain networks.
A newly developed chemo-immunological strategy enabled detection of acetoacetate-mediated lysine acetoacetylation, identified the associated regulatory enzymes, and revealed its distinct biological functions and physiological significance.
