Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Dissociable neural substrates of integration and segregation in exogenous attention

    Yujie Chen, Ai-Su Li ... Yang Zhang
    Dissociable neural signatures of integration and segregation provide the first direct neuroimaging evidence for the integration-segregation theory of exogenous attention.
    1. Neuroscience

    Modeling flexible behavior with remapping-based hippocampal sequence learning

    Yoshiki Ito, Taro Toyoizumi
    A biologically plausible reinforcement learning model that integrates associative memory and hippocampal remapping explains context-dependent flexible behavior, neural dynamics, and psychosis-related symptoms.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    The long non-coding RNA Dreg1 is required for optimal ILC2 development

    Sara Quon, Adelynn Tang ... Rhys Allan
    A Gata3 enhancer-embedded long non-coding RNA, Dreg1, was identified as being specifically required for optimal group 2 innate lymphoid cell development.
    1. Neuroscience

    Characterisation of cold-selective lamina I spinal projection neurons in the mouse

    Aimi N Razlan, Wenhui Ma ... Junichi Hachisuka
    Lamina I projection neurons that respond selectively to skin cooling receive monosynaptic input from Trpm8-expressing primary afferents and innervate brain regions involved in perception of cold and cold defence mechanisms.
    1. Immunology and Inflammation
    2. Neuroscience

    Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability

    Simone Carneiro-Nascimento, Chao Wei ... Dan Levy
    Intravital microscopy of meningeal macrophage Ca²⁺ dynamics reveals previously unknown population heterogeneity, vasomotion-coupled activity, and diverse responses during steady state and neuroinflammatory conditions, offering relevant insights into brain immune regulation.
    1. Neuroscience

    Endogenous corazonin signaling modulates the post-mating switch in behavior and physiology in females of the brown planthopper and Drosophila

    Ning Zhang, Shao-Cong Su ... Shun-Fan Wu
    Endogenous corazonin signaling is a conserved female-driven regulator of the post-mating response in insects.
    1. Neuroscience

    Cortical motor activity modulates respiration and reduces apnoea in neonates

    Coen S Zandvoort, Fatima Usman ... Caroline Hartley
    Communication between the cortex and respiration, known as cortico-respiratory coupling, occurs in newborn infants and relates to apnoea rate.
    1. Immunology and Inflammation

    HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane

    Adriana Quijada-Freire, César A Santiago ... Mario Mellado
    HIV-1 remodels the spatial organization of its co-receptor, CXCR4, on T cell membranes, showing that viral entry requires receptor clustering rather than simple receptor binding.
    1. Ecology
    2. Neuroscience

    Drift in individual behavioral phenotype as a strategy for unpredictable worlds

    Ryan T Maloney, Athena Q Ye ... Benjamin L de Bivort
    Individual flies have idiosyncratic preferences that shift over their lifetime in a way that depends on genotype and may be adaptive to rapidly changing environmental pressures.
    1. Neuroscience

    Regime shift detection and neurocomputational substrates for under and overreactions to change

    Mu-Chen Wang, George Wu, Shih-Wei Wu
    In a stylized regime-shift detection task, human fMRI evidence shows that under- and overreactions to change arise from dissociable contributions of the frontoparietal network and ventromedial prefrontal cortex.