Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A fully computationally designed SaCas9 variant expands PAM recognition to NNNRRT, achieving up to 116-fold higher editing at noncanonical sites while matching the performance of experimentally evolved variants.
Sara M Frangos, Henver S Brunetta ... Graham P Holloway
Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
Continuous flash suppression reduces V1 orientation responses in an ocular-dominance-dependent manner, which may still allow low-level coarse orientation discrimination but provide insufficient information for higher-level visual and cognitive tasks.
Alicja Monaghan, Richard AI Bethlehem ... Duncan E Astle
Contrary to prior work, principal axes of structural and functional connectivity are established early in life, remaining stable and undergoing refinement throughout development.
The first all-atom models of the mycobacterial outer membrane reveal how lipid organization and asymmetry generate a structurally heterogeneous barrier that underlies its unique permeability properties.
Soenke Cordeiro, Robert Patejdl ... Marianne A Musinszki
Identification of mangostins as potent BK channel activators links natural xanthones to vascular smooth muscle relaxation, providing a mechanistic basis for their reported antihypertensive effects.
A conserved neuropeptidergic circuit directly links internal glucose levels to sweet taste sensitivity, providing a central mechanism for coupling metabolic state to feeding behavior.
Friederike Steenken, Rainer Beutelmann ... Georg M Klump
In aging gerbils, compromised temporal fine structure perception is explained by a more prominent representation in auditory nerve fibers of temporal fluctuations of the signal envelope, rather than by synaptopathy.
Mark van der Kroeg, Sakshi Bansal ... Femke MS de Vrij
Human stem cell-derived adherent cortical organoids in 384-well plates provide a reproducible, long-term cortical organoid platform with neurons, glia, and robust network activity, enabling scalable disease modeling and therapeutic screening.
