Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Evolutionary Biology

    Diverse prey capture strategies in teleost larvae

    Duncan S Mearns, Sydney A Hunt ... Herwig Baier
    The evolution of hunting behavior in fish larvae has arrived at different, species-specific solutions, recombining a shared repertoire of locomotor and eye movement motifs.
    1. Immunology and Inflammation

    β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury

    Renaud Prevel, Erwan Pernet ... Maziar Divangahi
    β-Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.
    1. Microbiology and Infectious Disease

    Heat stress induces phage tolerance in Enterobacteriaceae

    Fan Zhang, Hao-Ze Chen ... Jia-Feng Liu
    Bacterial persistence against phages enables survival under infection, and heat treatment enhances this tolerance, facilitating resistance evolution and influencing the effectiveness of phage therapy.
    1. Structural Biology and Molecular Biophysics

    The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport

    Merissa Brousseau, Da Teng ... Katherine A Henzler-Wildman
    The C-terminal tail acts as a secondary gate to regulate substrate access into the primary binding site for transport across the membrane.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

    M Reza Bahranifard, Jessica Chan ... C Ross Ethier
    Magnetically steered mesenchymal stem cells significantly lowered intraocular pressure for 9 months in mice, motivating the translation of this technology for the treatment of glaucoma.
    1. Cell Biology

    The molecular logic of Gtr1/2- and Pib2-dependent TORC1 regulation in budding yeast

    Jacob H Cecil, Cristina M Padilla ... Andrew P Capaldi
    Dual regulation of TORC1 by Gtr1/2 and Pib2 drives cells into three distinct signaling states, establishing a new paradigm for graded TORC1 signaling.
    1. Cell Biology
    2. Medicine

    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

    Fan Zhang, Yuan Wang ... Xianpeng Ge
    CHMP5 is crucial in preventing skeletal progenitor cell senescence and abnormal bone formation, and senolytic drugs represent potential therapeutic medicine for musculoskeletal abnormalities associated with a dysfunctional endolysosomal pathway.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Drosophila hamlet mediates epithelial tissue assembly of the reproductive system

    Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
    Hamlet regulates heterotypic epithelial fusion by controlling spatial and temporal expression of known and novel epithelial regulators like Wnt and Tl pathway components, a mechanism potentially conserved through evolution.
    1. Plant Biology

    Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula

    Morgane Batzenschlager, Beatrice Lace ... Thomas Ott
    Imaging deep root tissues with a combination of cell-cycle reporters reveals that a cortical cell file traversed by symbiotic bacteria exhibits reduced proliferative potential and enters a prolonged G2 phase.
    1. Neuroscience

    Multifaceted role of galanin in brain excitability

    Nicolas N Rieser, Milena Ronchetti ... Stephan CF Neuhauss
    The neuropeptide galanin modulates whole-brain activity and stress responses in zebrafish, revealing a complex, receptor-dependent role in seizure regulation with implications for epilepsy, and related neurological disorders.