Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Depletion of the TGFβ signal-transducer, SMAD4, in granulosa cells of growing follicles reduces the number of filopodia, termed transzonal projections, that stably attach to and mediate communication with the oocyte.
Transgenic zebrafish generated by targeted genomic integration distinguish neuronal subtypes in the nucleus incertus that differ in their connections and functional properties.
Working memory representations are not hard copies of sensory information, even in early visual cortex, but can be recoded into more abstract and goal-directed formats aligned to behavioral goals.
Alterations of DNA methylation were associated with articular cartilage degeneration in hemophilic arthropathy, and aberrant methylation and expression of TNXB promote blood-induced chondrocyte apoptosis by regulating AKT activation.
Siena J Glenn, Zealon Gentry-Lear ... Arden Baylink
Enteric bacteria associated with bloodstream infections are attracted to human serum through L-serine and the chemoreceptor Tsr, and in an enterohemorrhagic lesion model use chemotaxis to invade damaged vasculature.
Ruby Oberin, Sigrid Petautschnig ... Patrick S Western
Growth-delayed offspring generated from eggs that lacked normal epigenetic programming exhibited a remarkable capacity to undergo late gestational fetal growth recovery, despite inefficient placental function.
Pau Vilimelis Aceituno, Dominic Dall'Osto, Ioannis Pisokas
Three theoretical principles explain the neural activity observed in the head direction circuit of insects, the connectivity pattern underlying the circuit, and how the ubiquitous eight-column circuit structure emerged from evolutionary processes.
