The cryo-EM structures of actomyosin-V, including a novel strongly bound post-rigor transition state, reveal a pronounced structural heterogeneity of myosin-V and the specific selection of the closed D-loop conformation of F-actin.

Cannabinoids inhibit neuronal expansion and growth through the rapid contraction of actomyosin.

B-cell integrin co-stimulation promotes the formation of an actomyosin network that drives integrin-dependent immune synapse formation and B-cell activation.

Oon and Prehoda discover cortical actomyosin dynamics that polarize asymmetrically dividing neural stem cells.

Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.

Developmentally controlled chiral counter-rotating actomyosin flows drive cell-lineage spindle skews and cell rearrangements during cytokinesis in early nematode development.

Cytokinetic actomyosin ring disassembly occurs through a novel mechanism in which the increased ring curvature, generated through contraction, itself promotes the disassembly process.

Novel mechanisms for cellular centering and symmetry breaking involving persistent contractile actomyosin flows and their hydrodynamic interactions with the fluid cytosol are presented and studied using a minimal, reconstituted system.

Boundary cell identity and sharpening of borders are coupled in hindbrain development since both are regulated by mechanical tension.

The actomyosin cytoskeleton generates active chiral torques that lead to left-right asymmetry in C. elegans embryos.