Computer simulations reveal the potential and limitations of recently proposed CRISPR-based cell lineage recorders, and suggest how the recorders' design can be optimised to yield more accurate cell lineage trees.

Single nucleus and single cell RNA-seq data uncover novel transcriptomic perspectives in Drosophila testis biology and provide access to user-friendly tools for further scientific discovery in the field.

Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.

Lineage specification and commitment are synchronized in the developing trophectoderm lineage of the mouse embryo, but are asynchronous events in the maturing inner cell mass, revealing a window of plasticity in this lineage.

LMO2 plays an important role in the maintenance of T lymphocyte competence and survival of pre-thymic progenitors by regulating the expression of Bcl11a and Tcf7 genes.

Epigenome and Mitochondrial Barcode of Lineage from Endogenous Mutations (EMBLEM) enable tracking cell lineage in combination with chromatin profile in ATAC-seq data.

A newly identified adipose lineage cell population, MALP, regulates marrow vasculature and osteogenesis in bone.

Developmentally controlled chiral counter-rotating actomyosin flows drive cell-lineage spindle skews and cell rearrangements during cytokinesis in early nematode development.

The combination of statistical inference and perturbation experiments reveals that trans-generational inheritance of cell size and cell-cycle speed, coupled through a minimum-size checkpoint, shapes paradoxical cell-cycle correlations in lineage trees.

A method for measuring p300 chromatin occupancy in specific lineages of mouse tissues was used to map endothelial enhancers and to identify previously unrecognized angiogenesis-related sequence motifs.