3,002 results found
    1. Chromosomes and Gene Expression

    Epigenetics: Linking environmental factors and gene regulation

    Signe Penner-Goeke, Elisabeth B Binder
    A technique called mSTARR-seq sheds light on how DNA methylation may shape responses to external stimuli by altering the activity of sequences that control gene expression.
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

    Anthony S Findley, Alan Monziani ... Francesca Luca
    Investigation of dynamic gene regulation across cell types and environments reveals new GxE regulatory loci that are important for disease.
    1. Genetics and Genomics
    2. Neuroscience

    Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

    Ximena Ibarra-Soria, Thiago S Nakahara ... Darren W Logan
    The neuronal composition of a mouse’s nose is individually unique due to a combination of olfactory experience and genetic variation local to olfactory receptor genes.
    1. Microbiology and Infectious Disease

    NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli

    Loïc Léger, Deborah Byrne ... Etienne Maisonneuve
    Genetic and biochemical approaches uncover a novel mode of regulation of the alarmone synthetase RelA through a functional and direct interaction with the small subunit of the nitrite reductase NirD.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

    Tingting Wang, Wenju Sun ... Jian Yan
    The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
    1. Computational and Systems Biology
    2. Neuroscience

    Regulation of sleep homeostasis by sexual arousal

    Esteban J Beckwith, Quentin Geissmann ... Giorgio F Gilestro
    Sexual arousal, exposure to aphrodisiac pheromones, or mere activation of peripheral pheromone-sensing neurons can modulate sleep homeostasis and are able to counteract the effects of sleep deprivation in Drosophila.
    1. Computational and Systems Biology

    Dynamic control of gene regulatory logic by seemingly redundant transcription factors

    Zohreh AkhavanAghdam, Joydeb Sinha ... Nan Hao
    Seemingly redundant homologous transcription factors play distinct and cooperative roles in time-dependent combinatorial gene regulation and enable dynamic control of heterogeneity in the gene responses to environmental stresses.
    1. Ecology

    Mapping the functional connectivity of ecosystem services supply across a regional landscape

    Rachel D Field, Lael Parrott
    Mapping functional relationships between multiple ecosystem services (ES) reveals previously unidentified areas of high ES value, which suggests that the spatial focus of planning for optimal ES provisioning may shift when relationships between several ES are considered.
    1. Plant Biology

    The transcriptional regulator BZR1 mediates trade-off between plant innate immunity and growth

    Rosa Lozano-Durán, Alberto P Macho ... Cyril Zipfel
    The transcriptional regulator BZR1 acts as a molecular integrator of environmental cues regulating the trade-off between growth and innate immunity.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A simple regulatory architecture allows learning the statistical structure of a changing environment

    Stefan Landmann, Caroline M Holmes, Mikhail Tikhonov
    Minimal modifications of common regulatory circuits can allow bacteria to learn from the past to better predict the future, on a physiological, rather than evolutionary, timescale.

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