Editors' Summary: This Replication Study has reproduced important parts of the original paper.

A regionally resolved single-cell RNA-sequencing analysis of GBM-associated leukocytes reveals distinct activation states of the main immune populations between tumor center, peripheral infiltration zone and blood.

The differentiation decisions made by pluripotent cells depend on their exposure to appropriate extrinsic signals and also on morphogenetic events that control receptivity to those differentiation cues.

Ribosome assembly is monitored to promote proteostatis through a system whereby unassembled ribosomal proteins lead to activation of heat shock factor 1 and inactivation of the RP gene activator Ifh1.

A project to repeat experiments from high-impact papers in cancer biology did not complete all replications, with challenges ranging from mundane reasons to unexpected methodological issues.

Inflammation reprograms the citrate cycle in adrenocortical cells leading to altered steroidogenesis.

Many tumors are depleted of mitochondrial DNA; this depletion is associated with changes in gene expression and with the incidence of critical somatic mutations and alterations.