Magazine

Highlighting the latest research and giving a voice to scientists
Illustration by Davide Bonazzi

Highlights

    1. Genetics and Genomics
    2. Neuroscience

    How stress can extend lifespan

    Loren Cocciolone, Valeria Uvarova, Patricija van Oosten-Hawle
    1. Neuroscience

    The power of chemogenetics

    Maria Puchik, Igor Kagan
    1. Structural Biology and Molecular Biophysics

    Enzyme dynamics revealed

    Álvaro de la Gándara, Agnieszka A Kendrick

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Latest articles

    1. Neuroscience

    Primate Research: Probing the staying power of chemogenetics

    Maria Puchik, Igor Kagan
    A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of nonhuman primates.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Neuroscience

    Aging: Unlocking the longevity code with stress

    Loren Cocciolone, Valeria Uvarova, Patricija van Oosten-Hawle
    Manipulating the neuronal pathway responsible for the hypoxic stress response in the worm C. elegans leads to an increase in lifespan.
    Version of Record
    Insight
    1. Developmental Biology

    Blastomeres: Tracing cell fates in embryos

    Ying Zhang, Qi Chen
    Differences in the activity of an enzyme called CARM1 influence the timing of blastomere polarization and whether they become part of the embryo or the placenta.
    Version of Record
    Insight
    1. Cancer Biology

    Transcription Factor-Dependent Cancers: Targeting chromatin remodeling complexes to treat uveal melanoma

    Jonas A Nilsson
    A novel compound that inhibits the BAF chromatin remodeling complex causes regression in an animal model of the incurable cancer uveal melanoma.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    Enzyme Dynamics: Capturing enzymes in motion

    Álvaro de la Gándara, Agnieszka A Kendrick
    A combination of cryogenic electron microscopy and molecular simulations has been used to study the structure and dynamics of an enzyme called ACE.
    Version of Record
    Insight
  1. Living Science: My grandmother’s rug

    Eve Marder
    The objects that migrants carry with them are tethers to the lives they have left behind.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Wnt Signaling: Exploring the origins of a signaling pathway

    Balaji Santhanam
    The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.
    Version of Record
    Insight
    1. Developmental Biology

    Morphogenesis: Regulating closure of the neural tube in humans

    Leon Qarawani, Jacob H Hanna
    An organoid-based screening platform that allows one-gene-at-a-time knockdown across a whole tissue has been used to identify the genes that regulate closure of the neural tube in humans.
    Version of Record
    Insight
  2. Episode 100: September 2025

    In this episode, we hear about poison frogs, gut microbiomes and disease, queen ants and gene therapy, tapeworms and epilepsy, and the double-edged nature of trained immunity.
    1. Neuroscience

    Numerical Cognition: Is ‘number sense’ a sense?

    Toshiya Matsushima
    Experiments on domestic chicks shed light on the links between brain lateralization and the left-to-right mental number line.
    Version of Record
    Insight