Jean-André Lapart, Marco Gottardo ... Bénédicte Durand
Genetic analyses in Drosophila establish the functional hierarchy of the ciliary transition zone module, Dzip1/Fam92/Cby, and reveal tissue specific variations in basal body anchoring pathways in fly ciliated tissues.
Super-resolution microscopy reveals a highly organized compartment in the stereocilia of mechanosensory hair cells of the inner ear, which is critical for hair cell function and affected in disease.
A pseudokinase in the secretory pathway, Fam20A, activates the real Golgi casein kinase, Fam20C, via a unique mechanism that is lost in human diseases.
Biochemical and structural investigations of the human tRNA ligase complex reveal the details of its molecular assembly and provide insights into the reaction mechanism of its catalytic subunit.
Transcriptomic and genomic analysis provides a resource of 50 primate-specific genes preferentially expressed in neural progenitors of fetal human neocortex, 15 of which are specific to humans.