43 results found
    1. Immunology and Inflammation

    Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells

    Chan-Su Park, Jian Guan ... Scheherazade Sadegh-Nasseri
    Fam49b is a critical regulator of selection process to ensure normal thymocyte development and peripheral T cells survival.
    1. Cell Biology
    2. Immunology and Inflammation

    FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

    Dongyang Wang, Xiaojing Zheng ... Haibin Xia
    Genetic and biochemical analyses in vitro and in vivo reveal how the novel protein FAM76B regulates inflammation.
    1. Cell Biology
    2. Developmental Biology

    Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila

    Jean-André Lapart, Marco Gottardo ... Bénédicte Durand
    Genetic analyses in Drosophila establish the functional hierarchy of the ciliary transition zone module, Dzip1/Fam92/Cby, and reveal tissue specific variations in basal body anchoring pathways in fly ciliated tissues.
    1. Neuroscience

    Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function

    Bo Zhao, Zizhen Wu, Ulrich Müller
    Super-resolution microscopy reveals a highly organized compartment in the stereocilia of mechanosensory hair cells of the inner ear, which is critical for hair cell function and affected in disease.
    1. Computational and Systems Biology

    A computational interactome and functional annotation for the human proteome

    José Ignacio Garzón, Lei Deng ... Barry Honig
    A machine-learning approach is used to predict 1.35 million interactions for 85% of the human proteome.
    1. Biochemistry and Chemical Biology

    A secretory kinase complex regulates extracellular protein phosphorylation

    Jixin Cui, Junyu Xiao ... Jack E Dixon
    A pseudokinase in the secretory pathway, Fam20A, activates the real Golgi casein kinase, Fam20C, via a unique mechanism that is lost in human diseases.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular architecture of the human tRNA ligase complex

    Alena Kroupova, Fabian Ackle ... Martin Jinek
    Biochemical and structural investigations of the human tRNA ligase complex reveal the details of its molecular assembly and provide insights into the reaction mechanism of its catalytic subunit.
    1. Developmental Biology
    2. Neuroscience

    Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex

    Marta Florio, Michael Heide ... Michael Hiller
    Transcriptomic and genomic analysis provides a resource of 50 primate-specific genes preferentially expressed in neural progenitors of fetal human neocortex, 15 of which are specific to humans.
    1. Stem Cells and Regenerative Medicine

    ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas

    Hanseul Yang, Daniel Schramek ... Elaine Fuchs
    Transcription factors of the ETS family govern a cohort of key cancer-associated regulators of malignancy in squamous cell carcinomas.
    1. Evolutionary Biology

    Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticity

    William R Thomas, Troy Richter ... Liliana M Dávalos
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing

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