Foxc1 proteins prepare the genomes of neural crest-derived cells to facilitate their later development into the cartilages that support the embryonic face.

Lineage specifiers FoxA1 and FoxA2 control lung cancer growth and identity by activating gastric differentiation and suppressing squamous cell carcinoma transdifferentiation.

Foxg1 regulates gliogenesis in the mouse neocortex by modulating FGF signalling and integrating intrinsic and extrinsic mechanisms to ensure a balanced production of neurons, astrocytes, and oligodendrocytes in the brain.

HSCB could be activated by PI3K signaling to facilitate FOG1 nuclear translocation to promote human erythropoiesis and megakaryopoiesis, highlighting an important, previously unrecognized iron–sulfur cluster delivery independent function of HSCB.

The basic helix-loop-helix transcription factor, HES3, acts downstream of the PAX3-FOXO1 fusion oncogene to impair muscle differentiation and promote tumorigenesis in rhabdomyosarcoma, a childhood muscle cancer.

Structural and biochemical analysis reveals that two intrinsically disordered domains of the transcription factor FoxM1 co-fold to form an autoinhibited conformation, which is disrupted by a specific activating phosphorylation event.

RNA processing regulates gene expression of the key transcription factor FOXP3 in T regulatory cells impacting immune tolerance and susceptibility to autoimmune disease.

Foxb1-expressing hypothalamic neurons in the parvafox nucleus and the dorsal premammillary nucleus both contribute to behavioral and physiological components associated with defensive behavior.

The mesenchyme surrounding the developing brain plays a significant role in controlling the fundamental growth and patterning of the cerebellum, and misregulation of this signalling can lead to important neurodevelopmental disorders.

Stimulation of endothelial glucose metabolism and vascular growth by genetic depletion of endothelial Foxo1 improves the whole-body response to a high-fat diet, by preserving adipose tissue functions and glucose homeostasis.