Mor Gross-Vered, Sébastien Trzebanski ... Steffen Jung
Detailed analysis of the sequence of monocyte differentiation into distinct gut tissue macrophages provides insights into monocyte biology and can serve as a platform for the design of cell therapies.
Computational pipeline SPICE systematically screens and predicts novel protein-protein binding complexes including the previously unrecognized global association and functional cooperation between IKZF1 and AP1.
HCN and SK channel currents in striatal cholinergic neurons are decreased with dopamine loss, but only HCN is restored by chronic L-DOPA and SK abnormality persists in dyskinesia.
Integrated analyses of acute myeloid leukemia genetics and epigenetics demonstrate that epigenetic evolution occurs in a convergent manner in the absence of DNA mutations at relapse post-chemotherapy.
Action-value signals previously found in many brain areas can be accounted for neither by concurrent serial correlations in neural activity and action value nor by signals for other decision variables.
Laura J Wagstaff, Jose A Gomez-Sanchez ... Kristjan R Jessen
In vivo experiments on transgenic mice, and cell culture studies, establish Schwann cell c-Jun as a central regulator of peripheral nerve repair, and repair failure, during aging and chronic denervation.
Coupling between subcellular localization and protein turnover of a neuronal stress kinase, DLK, and its role in neuronal stress responses in Drosophila.