Genetic and biochemical analyses demonstrate that cell-surface lectin receptors can potentially function as extracellular NAD+-binding receptors and provide direct evidence for extracellular NAD+ being a bona fide endogenous signaling molecule in plants.
New open-source method contains all the tools for extracting open chromatin or RNA from thousands of single cells in parallel for <5% of the cost of state-of-the-art commercial alternatives, paving the way for whole-tissue atlasing and new protocol development.
Genome-wide analysis of DNA methylation and accessible chromatin shows that retinal rods and cones have distinct epigenomic features that reflect differences in their development and function.
Locally activatable bioluminescence (LABL) is a genetically encoded reporter that allows real time, in vivo measurement of distinct clocks in different cells and tissues in Drosophila.
Two complexes that contain the histone acetyl transferase MOF have distinct regulatory roles in the growth and development of pluripotent embryonic stem cells
Roni O Maimon-Mor, Hunter R Schone ... Tamar R Makin
Biological- or artificial-arm experience during early development has a significant effect on artificial-arm motor control in adulthood, providing evidence for limited sensorimotor plasticity beyond childhood.
Marius E Moeller, Nathaniel V Mon Père ... Weini Huang
Single-cell and bulk sequencing data are combined through theoretical modeling to reveal the number of tissue-specific stem cells, mutation, and proliferation rates under sampling.
Benjamin R Kop, Yazan Shamli Oghli ... Lennart Verhagen
Realizing the clinical and neuroscientific potential of transcranial ultrasonic stimulation (TUS) requires careful control of the peripheral auditory confounds that underlie previously reported online motor inhibitory effects.