9,097 results found
    1. Cell Biology

    A quantitative inventory of yeast P body proteins reveals principles of composition and specificity

    Wenmin Xing, Denise Muhlrad ... Michael K Rosen
    Quantitative analyses of yeast P bodies reveals a small number of highly concentrated proteins and many weakly concentrated proteins, suggesting that the compartments are compositionally simpler than previously thought.
    1. Neuroscience

    Decoding the neural mechanisms of human tool use

    Jason P Gallivan, D Adam McLean ... Jody C Culham
    Imaging experiments reveal that some brain regions do not distinguish between actions performed using tools and those performed using the hands, while others represent these two types of action separately.
    1. Cancer Biology

    YAP/TAZ enhances P-body formation to promote tumorigenesis

    Xia Shen, Xiang Peng ... Chen-Ying Liu
    P-body is a new downstream effector of YAP/TAZ for tumorigenesis and tumor progression, suggesting disruption of P-bodies as a potential therapeutic strategy for tumors with active YAP.
    1. Neuroscience

    Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity

    Tom P Franken, Brian J Bondy ... Philip X Joris
    The location of impact sounds, common stimuli whose detection is crucial for survival, is encoded by a precise interaction between excitation and inhibition rather than coincidence detection of excitatory events.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

    Tatiana P Soares da Costa, Cody J Hall ... Matthew A Perugini
    Proof-of-principle for a new herbicide mode of action through the identification of novel inhibitors of lysine biosynthesis with in planta efficacy.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Context-dependent deposition and regulation of mRNAs in P-bodies

    Congwei Wang, Fabian Schmich ... Anne Spang
    An unbiased screen using various stresses reveals selective mRNA transport into P-bodies, in which mRNAs are either stored or decayed in a process that may promote chronological lifespan in yeast.
    1. Cell Biology

    Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

    Wondwossen M Yeshaw, Marianne van der Zwaag ... Ody CM Sibon
    VPS13A is associated with the endoplasmic reticulum, mitochondria and lipid droplets and is required for cellular processes that require interaction between these organells.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Coordination of two opposite flagella allows high-speed swimming and active turning of individual zoospores

    Quang D Tran, Eric Galiana ... Xavier Noblin
    Coordinated actions of two opposite flagella control speed and change direction of plant pathogen Phytophthora zoospores, in which the anterior flagellum is the main motor to generate thrust and spontaneously switch from reciprocal beating to breaststrokes to reorient its body.
    1. Cell Biology

    Pak1 kinase controls cell shape through ribonucleoprotein granules

    Joseph O Magliozzi, James B Moseley
    A newly discovered substrate of Pak1 kinase reveals novel mechanisms that control cell shape through regulated assembly of ribonucleoprotein granules.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

    Marcel Proske, Robert Janowski ... Dierk Niessing
    Structural promiscuity in PURA protein, induced by patient mutations, impacts nucleic acid binding, unwinding, and subcellular localization, indicating why so many patients display the full disease spectrum of PURA syndrome.

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