An enhancer-dependent transcriptional machinery finely tunes the expression of Ctnnb1 in intestinal crypts, thereby balancing homeostasis and tumorigenesis of intestinal epithelia.

Genome editing, advanced live-cell microscopy, and computational modeling were combined to measure WNT/CTNNB1 signaling parameters at the single molecule level, revealing critical regulatory nodes in this important signal transduction pathway.

Stem cells of the pituitary gland contribute to organ growth cell non-autonomously by promoting proliferation of committed progenitors through WNT ligand secretion.

Base editors, with improved specificity and expanded PAM sequence recognition, can be used in zebrafish for the rapid and efficient introduction of single base pair mutations.

Bi-allelic tagging enables the biophysical analysis of oncogenic β-catenin genetic variants in Wnt signaling.

Activation of Wnt/β-catenin signaling in endothelial progenitors derived from human pluripotent stem cells partially induces the specialized blood–brain barrier phenotype while the same treatment in matured endothelial cells is less efficacious.

A biochemical approach using the Wnt pathway as a model system demonstrates a new mechanism for specificity in interconnected signaling networks through scaffold-mediated shielding of bound proteins.

A novel population of adipocytes that play essential roles in adaptive thermogenesis via cell autonomous and non-autonomous effects and regulate systemic glucose metabolism in mice.

Mechanosensitive channels Piezo1/2 are required for osteoblast differentiation from progenitors by sensing fluid sheer stress and matrix rigidity and regulating NFATc1, YAP1 and ß-catenin activities through Ca²⁺ stimulated phosphatase calcineurin.

A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.