11,807 results found
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic effects on promoter usage are highly context-specific and contribute to complex traits

    Kaur Alasoo, Julia Rodrigues ... Daniel J Gaffney
    Re-analysis of large gene expression datasets with state-of-the-art quantification methods reveals additional candidate genes mediating complex trait associations.
    1. Neuroscience

    Clarifying the role of an unavailable distractor in human multiattribute choice

    Yinan Cao, Konstantinos Tsetsos
    A previously reported positive influence of a distractor alternative on decision accuracy was driven by an unintended covariation between key variables, beyond which the distractor has a modest negative influence on accuracy, possibly mirroring asymmetric multiattribute context effects.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context

    Atanas Radkov, Anne L Sapiro ... Seemay Chou
    Distinct surfaces of an interbacterial competition cell wall toxin mediate interactions with different cellular binding partners, resulting in an inherent evolutionary trade-off across the toxin superfamily.
    1. Neuroscience

    Contextual effects in sensorimotor adaptation adhere to associative learning rules

    Guy Avraham, Jordan A Taylor ... Samuel D McDougle
    Core associative learning phenomena that are observed in studies of eyeblink conditioning are also observed in sensorimotor adaptation, pointing to a common framework for these distinct cerebellar-dependent motor learning processes.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome

    Emma A Morrison, Samuel Bowerman ... Catherine A Musselman
    The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.
    1. Physics of Living Systems

    Adaptation of olfactory receptor abundances for efficient coding

    Tiberiu Teşileanu, Simona Cocco ... Vijay Balasubramanian
    A model of efficient coding by olfactory neurons explains context-dependence observed in the effect of perturbations to the olfactory environment.
    1. Chromosomes and Gene Expression

    The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo

    Jyothsna Visweswaraiah, Yvette Pittman ... Alan G Hinnebusch
    A structural element of mRNA exit channel protein Rps5 performs a critical role in start codon recognition during translation initiation by stabilizing initiator tRNA binding to the pre-initiation complex.
    1. Chromosomes and Gene Expression

    Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides

    Jamie R Wangen, Rachel Green
    Ribosome profiling reveals genome-wide stimulation of stop codon readthrough by aminoglycosides that is influenced sequence context.
    1. Genetics and Genomics
    2. Medicine

    Effects of lifelong testosterone exposure on health and disease using Mendelian randomization

    Pedrum Mohammadi-Shemirani, Michael Chong ... Guillaume Paré
    Long-term increased testosterone improved body composition and bone density, but lowered HDL and raised risks of hypertension, androgenic alopecia, prostate cancer, and spinal stenosis in males.
    1. Computational and Systems Biology

    Synthetic and genomic regulatory elements reveal aspects of cis-regulatory grammar in mouse embryonic stem cells

    Dana M King, Clarice Kit Yee Hong ... Barak A Cohen
    The independent effects of transcription factor binding sites are large regardless of sequence context, but the interactions between sites are context dependent.

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