309 results found
    1. Evolutionary Biology
    2. Physics of Living Systems

    Elastic instability during branchial ectoderm development causes folding of the Chlamydosaurus erectile frill

    Sophie A Montandon, Anamarija Fofonjka, Michel C Milinkovitch
    Robust wrinkling pattern of the frilled dragon’s spectacular erectile ruff emerges from an elastic instability during homogeneous growth of the embryonic neck fold frustrated by its attachment to adjacent tissues.
    1. Computational and Systems Biology

    Step-to-step variations in human running reveal how humans run without falling

    Nidhi Seethapathi, Manoj Srinivasan
    Natural step-to-step variations show how human running is stabilized, underscoring the importance of center of mass control and showing how humans run without falling despite muscle noise and uneven terrain.
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva, Adrian Jacobo ... A J Hudspeth
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Microtubules soften due to cross-sectional flattening

    Edvin Memet, Feodor Hilitski ... L Mahadevan
    A combination of experiments, theory, and simulations shows that the elastic softening of microtubules when they are bent arises due to the flattening of their tubular cross-section.
    1. Physics of Living Systems

    Mechanics and kinetics of dynamic instability

    Thomas CT Michaels, Shuo Feng ... L Mahadevan
    A theoretical framework for the growth of microtubules quantifies the roles of geometry, mechanics, kinetics and randomness and provides a phase diagram for dynamic instability in these self-assembled polymers.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Morphogenesis: Mathematical models with frills

    Pierre A Haas
    The spectacular frill around the neck of the lizard Chlamydosaurus has its origins in a mechanical instability that arises during development.
    Version of Record
    Insight
    1. Developmental Biology
    2. Physics of Living Systems

    Self-organized patterning of cell morphology via mechanosensitive feedback

    Natalie A Dye, Marko Popović ... Frank Jülicher
    Radial patterns of cell morphology in the Drosophila larval wing emerge through mechanosensitive dynamics of cell polarity.
    1. Developmental Biology
    2. Physics of Living Systems

    Optogenetic inhibition of actomyosin reveals mechanical bistability of the mesoderm epithelium during Drosophila mesoderm invagination

    Hanqing Guo, Michael Swan, Bing He
    Combined optogenetic and computer modeling approaches reveal how mechanical bistability of the mesoderm epithelium works jointly with apical constriction to facilitate mesoderm invagination in Drosophila, a well-characterized model for epithelial folding.
    1. Cell Biology
    2. Physics of Living Systems

    Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics

    Kai Weißenbruch, Justin Grewe ... Martin Bastmeyer
    The mechanical response of adherent cells in structured environments is shown to be shaped by the intricate interplay between the three different isoforms of an essential molecular motor.
    1. Cell Biology

    A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy

    Matthias Christoph Munder, Daniel Midtvedt ... Simon Alberti
    The cytoplasm behaves as an adaptable fluid that can reversibly transition into a protective solid-like state upon stress.

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