942 results found
    1. Genetics and Genomics

    High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models

    Thomas J O'Brien, Ida L Barlow ... André EX Brown
    High-throughput animal tracking and quantitative behaviour analysis detects diverse phenotypes in genetic disease models at a scale that makes drug screens possible.
    1. Computational and Systems Biology

    Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

    Morteza Chalabi Hajkarim, Ella Karjalainen ... Kyoung-Jae Won
    compaRe can be used to optimize cytometric high-parameter immunophenotypic characterization of heterogeneous cell populations.
    1. Neuroscience

    MAPLE (modular automated platform for large-scale experiments), a robot for integrated organism-handling and phenotyping

    Tom Alisch, James D Crall ... Benjamin L de Bivort
    A new versatile, autonomous, robotic experimental platform (MAPLE) can increase the throughput of biological experiments by automating the growth and phenotyping of a variety of model organisms.
    1. Plant Biology

    Arabidopsis transcriptome responses to low water potential using high-throughput plate assays

    Stephen Gonzalez, Joseph Swift ... Joseph R Ecker
    The 'low water' agar assay provides a reliable and practical high-throughput method for studying plant molecular signaling responses to drought stress.
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    1. Developmental Biology

    A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity

    Franz S Gruber, Zoe C Johnston ... Paul D Andrews
    A high-throughput phenotypic human sperm screening platform was developed which allows for major drug discovery programmes for male contraception.
    1. Neuroscience

    MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment

    Flavio H Beraldo, Daniel Palmer ... Marco AM Prado
    Comprehensive dataset of high-level cognitive assessment in mouse models of neurodegeneration, accompanied by an open-access database/repository to change the paradigm of how cognitive studies in animal models can be shared/re-used.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pyphe, a python toolbox for assessing microbial growth and cell viability in high-throughput colony screens

    Stephan Kamrad, María Rodríguez-López ... Jürg Bähler
    An open-source python package for phenotype analyses provides a versatile, modular and user-friendly solution to determine complementary fitness-related traits from large-scale assays of microbial colonies.
    1. Medicine

    Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer

    Marinus Huber, Kosmas V Kepesidis ... Mihaela Zigman
    The combination of molecular infrared fingerprinting and machine learning enables the detection of breast, bladder, prostate, and lung cancer based on liquid blood serum and plasma, providing a general framework for the minimally invasive investigation of oncological conditions.
    1. Computational and Systems Biology
    2. Medicine

    Diagnostically relevant facial gestalt information from ordinary photos

    Quentin Ferry, Julia Steinberg ... Christoffer Nellåker
    An automatic computer vision analysis approach can assist in the diagnosis of rare genetic disorders by using ordinary photographs of patients.
    1. Genetics and Genomics

    Functional profiling of long intergenic non-coding RNAs in fission yeast

    Maria Rodriguez-Lopez, Shajahan Anver ... Jürg Bähler
    Phenomics assays reveal hundreds of mutant phenotypes for long non-coding RNAs grown in specific environmental or physiological contexts, indicating that most of these RNAs exert cellular functions under certain conditions.

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