5,979 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks

    Eugenia Lyashenko, Mario Niepel ... Dennis Vitkup
    Preferential endocytosis of activated receptors allows cells to memorize their past and perform relative sensing.
    1. Neuroscience

    The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

    Stephen W Santoro, Catherine Dulac
    A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
    1. Neuroscience

    The cation channel TRPA1 tunes mosquito thermotaxis to host temperatures

    Román A Corfas, Leslie B Vosshall
    Female mosquitoes are exquisitely sensitive to human body heat, and the TRPA1 gene is required to focus their attraction toward thermal stimuli resembling warm-blooded hosts.
    1. Neuroscience

    High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila

    Rui Huang, Tingting Song ... Liming Wang
    Fruit flies fed with high-fats diets are hyper-sensitive to a hunger hormone AKH and exhibit enhanced food-seeking behavior when starved.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells

    Léa Torcq, Sara Majello ... Anne A Schmidt
    Pre-hematopoietic stem cells emerge from the aortic floor according to two radically different morphodynamics whose biomechanics rely on controlling apicobasal polarity in hemogenic precursors, which may impact on their fate.
    1. Computational and Systems Biology
    2. Neuroscience

    Phase response analyses support a relaxation oscillator model of locomotor rhythm generation in Caenorhabditis elegans

    Hongfei Ji, Anthony D Fouad ... Christopher Fang-Yen
    Behavioral, optogenetic, and computational modeling analyses show that the roundworm Caenorhabditis elegans uses a relaxation oscillation mechanism to generate rhythmic locomotor patterns.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration

    Yang Bai, Caiyun He ... Xiongfei Fu
    Bacterial population can coordinate individuals of different phenotypes by spatial modulation of their run-and-tumble behaviors, resulting in collective group migration with an ordered structure of phenotypes.
    1. Physics of Living Systems

    Theory for the optimal detection of time-varying signals in cellular sensing systems

    Giulia Malaguti, Pieter Rein ten Wolde
    A theory is presented for the optimal design of cellular sensing systems that maximizes the sensing precision given resource constraints.
    1. Physics of Living Systems

    Vein fate determined by flow-based but time-delayed integration of network architecture

    Sophie Marbach, Noah Ziethen ... Karen Alim
    Relative hydraulic resistance, shear rate, and pressure in a vascular network integrate the network's architecture via fluid flow, and determine vein dynamics, with a time delay, in the prototypical organism Physarum polycephalum.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

    Timothy J Wendorff, James M Berger
    The engagement of DNA crossings is shown to license ATP hydrolysis and DNA cleavage by topoisomerase VI, a finding with mechanistic ramifications for related GHKL ATPases and meiotic recombination machineries.

Refine your results by:

Type
Research categories